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Queen's University

William G. Bendena - Professor

Bendena.jpg Research: Managing the insect pest problem in Canadian forestry and agriculture is a key economic, health and environmental issue for Canada.  Replacing current chemical controls with more environmentally benign biological treatments is based on understanding the biology of the organism. For example, how do insects change from one form to another as they grow?  What controls how females produce eggs?  How do chemical signals from the brain control maturation and reproduction. What controls an insect’s choice between staying in one location to feed or travel long distances? The answer to these questions relates back to the nervous system and chemical messengers that regulate hormone systems that in turn have downstream effects on behaviour.

We have used genetically manipulatable organisms such as Drosophila melanogastervand Caenorhabditis elegans to identify and manipulate small proteins (neuropeptides) of the nervous system and their G-protein coupled receptors to uncover effects on behaviours that may result in changing the organism;s locomotion, growth and/or reproduction.

Our recent work with C. elegans has uncovered a specialized neuropeptide receptor that links the nervous system to fat accumulation (obesity).

»» No Lab Website »« email: »« telephone: 613-533-6121 ««

Some Recent Publications:

    • BENDENA, W.G, ZHANG, J-R., BURTENSHAW, S.M. and TOBE,S.S. (2011) Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. Gen. Comp. Endocrinol. In Press.
    • BENDENA, W.G. (2010) Neuropeptide Physiology in Insects, Advances in Experimental Medicine and Biology 692:, 166-191.
    • ZHANG, H., TIAN, L., TOBE, S., XIONG, Y., WANG, S., LIN, X., LIU, Y., BENDENA, W.G., LI, S. and ZHANG, Y. (2010) Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene. Biochem. Biophys. Res. Commun. 401(2):182-187.
    • MARTINEZ-PERES, F., BENDENA, W.G., CHANG, B. and TOBE, S.S. (2010) Influence of codon usage bias in FGLamide-allatostatin mRNA secondary structure.  Peptides Epub ahead of print, Oct13.
    • ZHOU, S., ZHOU, Q., LIU, Y., WANG, S., WEN, D., HE, Q., WANG, W., BENDENA, W.G., and LI, S. (2010) Two Tor genes in the silkworm Bombyx mori.  Insect Mol. Biol. 19(6) 727-735.
    • HAYWARD, A., TAKAHASHI, T., BENDENA, W.G., TOBE, S.S. and HUI, J.H.L. (2010)      Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer  proteins in metazoans. FEBS Lett. 584(6): 1273-1278.
    • WANG, S., LIU, S., LIU, H., WANG, J., ZHOU, S., JIANG, R-J., BENDENA, W.G., and LI, S. (2010) The insect steroid hormone 20-hydroxyecdysone reduces food consumption resulting in fat body lipolysis during molting and pupation. J. Mol. Cell Biol. 2(3): 128-138.
    • LIU, Y., ZHOU, S., MA,L., TIAN,L., WANG, S., SHENG, Z., JIANG, R-J., BENDENA, W.G. and LI, S. (2010) Transcriptional regulation of the insulin signaling pathway genes by starvation and 20-hydroxyecdysone in the Bombyx fat body.  J. Insect Physiol. 56(10): 1436-1444.
    • HUI, J.H.L., HAYWARD, A., BENDENA, W.G., TAKAHASHI, T., and TOBE, S.S. (2010) Evolution and functional divergence of enzymes involved in sesquiterpenoid biosynthesis in crustaceans and insects. Peptides 31: 451-455.
    • MARTINEZ-PERES, F., BENDENA, W.G., CHANG, B., TOBE, S.S. (2009) The FGL-amide allatostatin gene in arthropods: introns early or late? Peptides.7: 1241-1248.
    • LIU, Y.,  SHENG, Z., LIU, H., WEN, D., HE, Q., WANG, S., SHAO,W.,  JIANG, R., AN, S., SUN, Y., BENDENA, W.G., WANG,J.,  GILBERT, L.I., WILSON,T.G., SONG, Q. and LI, S. (2009) Juvenile hormone overturns the transcriptional activity of Met/Gce and thus modulates the action of 20-hydroxyecdsyone in Drosophila fat body Development 136: 2015-2025.
    • BENDENA, W.G., BOUDREAU, J.R., PAPANICOLAOU, T., MALTBY, M, TOBE, S.S.and CHIN-SANG, I. (2008) A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues. Proc. Natl. Acad. Sci. (USA). Jan 29 105 (4): 1339-1342.
    • LUNGCHUKIET, P.,  DONLY, B.C.,  ZHANG, J., TOBE, S.S. and BENDENA, W.G. (2008) Molecular cloning and characterization of an allatostatin-like receptor in the cockroach Diploptera punctata. Peptides 29: 276-285.
    • LUNGCHUKIET, P., ZHANG, P., TOBE, S.S. and BENDENA, W.G.(2008) Quantification of allatostatin receptor mRNA levels in tissues of  the cockroach, Diploptera punctata, using Real time RT-PCR  J. Insect Physiol. 54 (6), 981-987.
    • BURTENSHAW, S.M., SU,P.P., ZHANG, J.R.,  TOBE, S.S., DAYTON, L. and. BENDENA, W.G. (2008) A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): relationship to juvenile hormone biosynthesis? Peptides 29:242-251.

      Kingston, Ontario, Canada. K7L 3N6. 613.533.2000