Adam Chippindale - Associate Professor
Research: The evolutionary arms race between an organism and its enemies is known as the 'Red Queen' process. Because each species is a moving target, open-ended cycles of adaptation and counter-adaptation can ensue without any 'progress' being made. Increasingly we recognize that wherever genetic entities interact we are likely to find conflict and RQ-style antagonistic coevolution. The conflict between females and males, generated by disparate fitness goals and a shared genome, is of particular interest because they are constant components of one another's environments. Long-term goals of my research program include understanding (i) the evolution of sex and separate genders; (ii) the ways that genetic conflict shapes genome organization; (iii) the mechanisms that maintain genetic variation for fitness; and (iv) the genetic architecture of life-history and stress-resistance traits.
For experimental work, we use the fruit fly, Drosophila melanogaster, a wide range of tools and expertise derived from nearly a century of research using this organism, and some new approaches to evolutionary genetics. For example, we have developed cytogenetic systems for cloning the entire fly genome (or any part thereof) and measuring Darwinian fitness and its components under normal conditions. These sensitive techniques have allowed us to explore uncharted waters in evolutionary genetics. We also apply experimental evolution to directly observe the process of adaptation and the relationships between growth, survival, and reproduction.
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Some Recent Publications:
- Jiang. P., S. Bedhomme, N.G. Prasad, and A.K. Chippindale 2011. Sperm competition and mate harm unresponsive to male-limited selection in Drosophila: An evolving genetic architecture under domestication. In Press Evolution.
- Mallet, M.A. and A.K. Chippindale 2011. Inbreeding reveals stronger net selection on Drosophila melanogaster males: implications for mutation load and the fitness of sexual females. Heredity. Published online 1 December 2010. (see also News and Commentary by A.F. Agrawal “Stronger Selection on Males. Are males the more ‘sensitive’ sex?”)
- Abbott, J.K., S. Bedhomme and A. K. Chippindale 2010. Sexual conflict in wing size and shape in Drosophila melanogaster. Journal of Evolutionary Biology 23 (9): 1989–1997.
- Kwan, L., S. Bedhomme, N.G. Prasad, and A.K. Chippindale. Sexual conflict and environmental change: trade-offs within and between the sexes during the evolution of desiccation resistance. Journal of Genetics 87(4):383-94, 2008.
- Bedhomme S, N.G. Prasad, P-P. Jiang, and A.K. Chippindale 2008. Reproductive behaviour evolves rapidly When intralocus sexual conflict Is removed. PLoS ONE 3(5): e2187.
- Prasad, N.G., S. Bedhomme, T. Day and A.K. Chippindale. 2007. An evolutionary cost of separate genders revealed by male-limited evolution. American Naturalist 169: 29-37.
- Bedhomme, S. and A.K. Chippindale. Irreconcilable differences: When sexual dimorphism fails to resolve sexual conflict. In: SEX, SIZE AND GENDER ROLES: Evolutionary Studies of Sexual Size Dimorphism. Oxford University Press. pp. 185–194.
- Prasad, N.G., S. Bedhomme, T.Day, and A.K. Chippindale 2007. A new cost of sex revealed by male-limited experimental evolution. American Naturalist 169: 29-37.
- Pischedda, A. and A.K. Chippindale 2006. Intralocus sexual conflict diminishes the benefits of sexual selection. PLoS Biol 4(11): e356. doi:10.1371/journal.pbio.0040356.
- Long, T.A.F., R. Montgomerie, and A. Chippindale 2006. Measuring the gender load: Can population crosses reveal sexual conflict? Philosophical Transactions of the Royal Society of London, Series B. Volume 361, Number 1466: 363-374.
- Chippindale, A.K. 2006. Experimental Evolution. Ch. 31 in Evolutionary Genetics, C. Fox and J. Wolf (eds.). Oxford University Press.
- Pischedda, A. and A. Chippindale 2005. Sex, mutation and fitness: asymmetric costs and routes to recovery. Journal of Evolutionary Biology 18(4): 1115-1123.