Peter Hodson - Professor
Research: Fish Toxicology
- Effect of chemical metabolism on chemical toxicity
- Polynuclear aromatic hydrocarbons, complex mixtures
- The effect of chemical dispersants on the toxicity of spilled oil to fish
- Identification of the components of oil that cause toxicity
- Tools for assessing exposure and effects (biomarkers)
- Toxic equivalent factors based on structure-activity; bioassays of short-term indicators
- Responses of fish populations (especially American eel) to chemical stress
- The role of food webs in transferring mercury from sediments to fish
- The history of pesticide use in the St. Lawrence R.
My current interest is the role of metabolism in chemical toxicity to fish, with a focus on the reactive by-products of polynuclear aromatic hydrocarbon (PAH) metabolism by liver cytochrome P450 or CYP1A enzymes. The goal is to understand the mechanism of PAH toxicity, specifically of the alkyl-substituted forms, to the early life stages (embryos and larvae) of fish and the consequences for larval survival and recruitment. The results are directly applicable to ecological risk assessment of PAHs from oil, coal tar, creosote, soot and the by-products of microbial degradation of resin acids from pulp mill effluents.
My research is currently supported by grants from the Natural Sciences and Engineering Research Council
, the Department of Fisheries and Oceans, and the Ontario Ministry of the Environment. These grants facilitate collaboration with other scientists at Queen’s, University of Waterloo, university of Massachusetts, the Université de Québec à Rimouski, Environment Canada, Fisheries and Oceans, Ontario Ministry of Natural Resources, Ontario Ministry of the Environment, and the Ministère des Ressources Naturelles et de la Faune de Québec.
Some Recent Publications (students in bold):
- Wu, D., Wang, Z., Hollebone, B., McIntosh, S., King, T., Hodson, P.V. 2012. Comparative toxicity of four chemically-dispersed and undispersed crude oils to rainbow trout embryos. Environ Toxicol Chem 31:754-765
- Arthur, T., Harjani, J.R., Phan, L., Scott, L.M., Jessop, P.G., Hodson, P.V. 2012. Effects-driven chemical design: the acute toxicity of CO2-triggered switchable surfactants to rainbow trout can be predicted from octanol-water partition coefficients. Green Chem 15:357-362. DOI: 10.1039/C1GC15620A
- Fallahtafti, S., Rantanen, T., Brown, R.S., Snieckus, V., Hodson, P.V. 2012. Toxicity of hydroxylated alkyl-phenanthrenes to the early life stages of Japanese medaka (Oryzias latipes). Aq. Tox. 106-107:56-64 doi:10.1016/j.aquatox.2011.10.007 publ ol 8 /11/11
- Turcotte, D., Akhtar, P., Bowerman, M., Kiparissis, Y., Brown, R.S., Hodson, P.V. 2011. Measuring the toxicity of alkyl-phenanthrenes to early life stages of medaka (Oryzias latipes) using partition controlled delivery. Environ Toxicol Chem 30:487–495, 2011(doi: 10.1002/etc.404)
- Scott, JA, Incardona, JP, Pelkki, K, Shepardson, S, Hodson, P.V. 2011.AhR2-mediated, CYP1A-independent cardiovascular toxicity in zebrafish (Danio rerio) embryos exposed to retene. Aq. Tox 101:165–174. doi:10.1016/j.aquatox.2010.09.016 (publ on-line Nov 5, 2010)
- McIntosh, S, King, T, Wu, D, Hodson, PV. 2010. Toxicity of dispersed crude oil to early life stages of Atlantic herring (Clupea harengus). Environ Toxicol. Chem 29:1160-1167
- Ridal, J.J., E. Yanch, A. Fowlie, N.R. Razavi, T. Delongchamp, M. Fathi, P.V. Hodson, L.M. Campbell, J.M. Blais, M.B.C. Hickey, E. Yumihovize, and D.R.S. Lean. 2010. Potential Causes of Accelerated Transfer of Sediment Mercury to St. Lawrence River Biota: Implications for Sediment Management Strategies at Cornwall, Ontario, Canada. Hydrobiologia 647:81-98.
- Kelly, EN, Short, JW, Schindler, DW, Hodson, PV, Ma, M, Kwan, AK, Fortin, BL. 2009. Oil sands development contributes polycyclic aromatic compounds to the Athabasca River and its tributaries. PNAS 106:22346-22351. www.pnas.org/cgi/doi/10.1073/pnas.0912050106
- Schein, A, JA Scott, L Mos, PV Hodson. 2009. Chemical dispersant increases the apparent bioavailability and toxicity of diesel to rainbow trout (Oncorhynchus mykiss). Env. Tox. Chem. 28:595-602
- Springman, KR, JW Short, MR Lindeberg, JM Maselko, C Khan, PV Hodson, SD Rice. 2008. Semipermeable membrane devices link site-specific contaminants to effects: Part I - induction of CYP1A in rainbow trout from contaminants in Prince William Sound, Alaska. Mar. Environ Res. 66:477-486.