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Queen's University

Chris Moyes - Professor

Moyes.jpg Research: We study how the metabolic properties of muscle are governed in relation to evolution, development, and stress, both physiological and environmental: how evolutionary processes influence the diversity in muscle bioenergetics across species and populations, how muscle metabolic genes are regulated in myogenesis, development, physiological remodelling and metabolic pathologies, how animals change muscle bioenergetics in response to environmental stressors, such as temperature and hypoxia.  In all of our studies we attempt to integrate across biological levels of organization, from molecular biology to population biology.

»» Lab Website »« email: »« telephone: 613-533-6157 ««

Some Recent Publications:

  • Davies, R,  KE Mathers, AD Hume, K Bremer, Y Wang, and CD Moyes (2012) Hybridization in sunfish influences the muscle metabolic phenotype. Physiol Biochem Zool 85: 321-331.
  • Little, AG, SC Lougheed, and CD Moyes (2012) Evolution of mitochondrial-encoded cytochrome oxidase subunits in endothermic fish. Molecular Phylogen Evol 63: 679-684
  • Bremer, K, CT Monk, BJ Gird, and CD Moyes (2012) Transcriptional regulation of temperature-induced remodelling of muscle bioenergetics in goldfish. Am J Physiol Reg Integ Comp Physiol 303: R150-R158.
  • Kocha KM, CE Genge and CD Moyes (2011) Origins of interspecies differences in mammalian muscle metabolic enzymes. Physiol Genomics 43: 873-883.
  • Gurd BJ, Y Yoshida, JT McFarlan, CD Moyes, GJF Heigenhauser, L Spriet and A Bonen (2011) Nuclear SIRT1 activity but not protein content regulates mitochondrial biogenesis in rat and human skeletal muscle. Am J Physiol Reg Integ Comp Physiol 310: R67-75.
  • Musyl MK, RW Brill, DS Curran, NM Fragoso, LM McNaughton, A Nielsen, BS Kikkawa and CD Moyes. Post-release survival, vertical and horizontal movements, and thermal habitats of five species of pelagic sharks in the central Pacific Ocean. Fisheries Bulletin 109: 341-368.
  • Duggan A, KM Kocha, CT Monk, K Bremer and CD Moyes. Coordination of cytochrome c oxidase gene expression in the remodeling of skeletal muscle. J Exp Biol 214: 1880-1887.
  • Bremer K and CD Moyes (2011) Origins of variation in muscle cytochrome oxidase activity within and between fish species. J Exp Biol 214: 1888-1895.
  • Davies R, Y Wang and CD Moyes (2011) Intra- and inter-specific variation in metabolic gene expression in relationship to environmental hypoxia. Comp Biochem Physiol A Mol Integ Physiol 159: 25-31.
  • Little, AG, KM Kocha, SC Lougheed, and CD Moyes (2010) Evolution of the nuclear-encoded cytochrome oxidase subunits in vertebrates. Physiol Genomics 42:76-84.
  • Little, AG, SC Lougheed and CD Moyes. (2010) Evolutionary affinity For billfishes (Xiphidae and Istiophoridae) and flatfishes (Pleuronectiformes): independent and trans-ordinal origins for endothermy in teleosts. Mol Phylogen Evol 56:897-904.
  • LeMoine, CMR, SC Lougheed and CD Moyes (2010) Modular evolution of PGC-1 in vertebrates. J Mol Evol 70:492-505
  • Seebacher, F, MD Brand, PL Else, H Guderley, AJ Hulbert and CD Moyes. (2010) Plasticity of vertebrate oxidative metabolism in variable climates: molecular mechanisms.  Physiol Biochem Zool  83:721-32
  • Moyes CD and CE Genge. (2010) Scaling of muscle metabolic enzymes: an historical perspective. Comp Biochem Physiol A Mol Integ Physiol  156: 344-350.

Kingston, Ontario, Canada. K7L 3N6. 613.533.2000