Laurent Seroude - Professor
Research: The research in our group uses genetics to dissect the molecular changes associated with aging and identify genes controlling how we age. The general strategy is to use Drosophila as a model system in which to identify and isolate genes homologous to humans, using the fly for experimental analysis of their basic functions. Why flies?
The molecular cloning and functional analysis of Drosophila genes have shed light on many biological processes. Cloned Drosophila genes have led to the identification of mammalian cognates and to an extend no one predicted many of these cognates have closely related functions in mammals, including humans.
Drosophila has enormously contributed to the understanding of many basic cellular functions. Examples include transcription factors and their regulatory targets, structural proteins, chromosomal proteins, ion channels and signaling proteins. Considering how flies and humans look so different, the most incredible outcome of Drosophila research is that conservation also extends to higher order processes such as the one involved in development, immunity, behavior, sleep, olfaction, neurodegeneration and responses to drugs such as cocaine and alcohol.
Lab Website »« email: email@example.com »« telephone: 613-533-6769 ««
- Luc Poirier, Amanda Shane, Jie Zheng and Laurent Seroude. Characterization of the Drosophila Gene-Switch system in aging studies: a cautionary tale. Aging Cell 7: 758-770 (2008)
- Sean Ramsden, Yeuk Yu Cheung and Laurent Seroude. Functional analysis of the Drosophila immune response during aging. Aging Cell 7: 225-236 (2008)
- Viara Mileva-Seitz, Chengfeng Xiao, Laurent Seroude, and R. Meldrum Robertson. Tissue-specific targeting of Hsp26 has no effect on heat resistance of neural function in larval Drosophila. Cell Stress & Chaperones DOI: 10.1379/CSC-313 (2007)
- Chengfeng Xiao, Viara Mileva-Seitz, Laurent Seroude, and R. Meldrum Robertson. Targeting HSP70 to motorneurons protects locomotor activity from hyperthermia in Drosophila. Dev Neurobiology 67: 438-455 (2007)
- Markus K. Klose, David Chu, Chengfeng Xiao, Laurent Seroude, and R. Meldrum Robertson. Heat shock-mediated thermoprotection of larval locomotion compromised by ubiquitous overexpression of Hsp70 in Drosophila melanogaster.
J Neurophysiology 94: 3563-3572 (2005)
- Jie Zheng, Scott W. Edelman, Grace Tharmarajah, David W. Walker, Scott D. Pletcher and Laurent Seroude. Differential patterns of apoptosis in response to aging in Drosophila. PNAS 102: 12083-12088 (2005)