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Graduate Studies Courses of Instruction Biochemistry


Biochemistry
The following courses will be offered in the graduate program.
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QACS-799* Introduction to Animal Care
This non-credit WebCT course is entirely online and self-directed. It is offered every semester and is obligatory for all students undertaking research, teaching or testing involving the use of vertebrate animals. It should be taken before any animal work is begun. The course will cover ethical and legal obligations related to the use of animals; standards of care; sources of animals; how health and disease affect research data; humane endpoints; principles of anesthesia and recovery surgery. Students need to take this seminar only once. Students who passed LISC-488 are exempt from QACS 799.  Exclusions: LISC-488.  Every semester; WebCT; Animal Care Service
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BCHM-810* Protein Structure and Function 3L/T
This course presents an integrated approach to the study of protein function.  Topics include proteomic techniques in protein profiling, mass spectrometry, 2-D gel electrophoresis, yeast 2-hybrid analysis, protein chips, protein purification, imaging, surface plasmon resonance, calorimetry, bioinformatics and protein evolution, protein modifications and processing, interpretation and applications of 3-D structure, protein structure-function relationships. Three lecture hours per week; Fall. A. Mak.  Offered 2009-2010. Offered jointly with BCHM-410* with additional work required. PRE-REQUISITES:  BCHM-310 or 315*/316*/317* or permission of the instructor.
EXCLUSION: BCHM-410*
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BCHM-811* Advanced Molecular Biology 3L/T
This course concentrates on the molecular biology of mammalian models particularly mechanisms involved in human diseases. The human genome project, forensic analysis, DNA diagnostics of human diseases, models of transcriptional and growth regulation and cancer, DNA repair, RNA processing and translation are all discussed. Emphasis on recent findings and course materials will be drawn from current reviews.
Three lecture hours per week.  Winter. C. Mueller.  Offered 2009-2010. Offered jointly with BCHM-411* with additional work required. 
PREREQUISITE: BCHM-310 or 315*/316*/317* or permission of the instructor
EXCLUSION: BCHM-411*.
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BCHM-820* Advanced Topics in Molecular Biology
Discussions and presentations on current topics in molecular biology.  The emphasis will be on mammalian systems and will cover a wide range of topics relating to recent advances in molecular biology.  Typical topics include gene regulation, replication, DNA repair, forensic analysis, human genomics and genetics.  Marks are based on student presentations and essays typically in "News and Views" or Mini-Review formats.  Three hours per week, presentations and discussions of original papers.  Fall;  Alternate years;  C. Mueller.  Not offered 2009-2010.
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BCHM-822* Mechanisms of Metabolic Control
Lectures and discussions on mechanisms of metabolic control. Recent research on a wide range of specific metabolic systems is examined critically. Emphasis is placed on biochemical factors and principles which play a role in the integration and control of metabolism.
Lectures and seminars, three hours per week; Winter; Alternate years.  Offered 2009-2010.
PREREQUISITE: BCHM-431* or equivalent.
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BCHM-823* Advances in Protein Structure and Function
This course consists of weekly presentations and discussions of recent advances towards the understanding of protein structure and function. Topics of discussion include novel approaches, techniques and concepts in the discovery of protein functions. Students will develop skills in literature research, critical evaluation of published work, effective presentation and discussion of papers.A specific theme, such as cell motility, may be used to illustrate research approaches employed to study biological systems in general. Three lecture hours per week; Winter; Alternate years;A. Mak. Not offered 2009-2010. PREREQUISITE: BCHM-410* or equivalent.
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BCHM-824* Topics in Biophysical Chemistry
This course will consist of seminars and lectures generally based on topics such as equilibrium binding, enzyme kinetics, hydrodynamics and spectroscopy. Protein structure determination using methods such as x-ray crystallography and protein NMR will be covered. Specific emphasis will be placed on topics related to the interests and research projects of the students taking the course. The course will include a practical component involving hands-on experience with state of the art physical biochemical tools. This component will require 15-20 hours of the students time.Three lecture hours per week; Fall;M.E. Nesheim.Offered 2009-2010. PREREQUISITE: BCHM-313 or its equivalent.
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BCHM-828*/928* Research Project in Biochemistry
This course is intended to provide the student with the opportunity to gain familiarity with their research field. Students will review the literature related to their proposed graduate research thesis project and write a series of essays on topics selected in consultation with their supervisor; these will be evaluated by a supervisory committee consisting of their supervisor and two other faculty members. They will also develop a written draft research proposal that will be presented to their supervisory committee and defended in a final oral examination. This course is not mandatory but is highly recommended to be taken by students in the first full term of the graduate program. Z. Jia (course coordinator).  Offered 2009-2010.
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BCHM-830 Biochemistry Seminar Program for M.Sc. students
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BCHM-832* Molecular Basis of Cell Function
Principles of regulatory mechanisms; regulation of cellular function and growth by oncogenes, growth factors, isoprenoids and steroid hormones. Receptors, second messengers and protein phosphorylation. Correlation of cell ultrastructure with biochemical function. The components, assembly, metabolism and evolution of cellular structures are described.  Offered jointly with BCHM 432. Three lecture hourse per week; Fall; G.P. Côté.  Offered 2009-2010. PREREQUISITE: BCHM 310, or BCHM 315 and BCHM 316 and BCHM 317 for BCHM students; BCHM 310, or BCHM 315 and BCHM 316 for LISC students.
EXCLUSION: BCHM432 (BCHM 431,BCHM 433, BCHM 831* and BCHM 833*).
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BCHM-841* Current Topics in Biochemistry I
Discussion of recent advances in biochemistry in which students will be expected to make a positive contribution.
Half course lectures and seminars; fall and winter.
Alternate years.  2.5 hours per week, half course lectures and seminars; Fall and Winter.  Offered 2009-2010.
PREREQUISITES: BCHM-410* and 411* (or equivalent) which may be taken concurrently.
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BCHM-875* Bioinformatics
This inter-disciplinary course, designed for students in the computational and life sciences, looks at the application of computing concepts and techniques to problems in molecular biology. It demonstrates the application of a variety of computational tools for the analysis and understanding of molecular sequence and structure data. Topics may include: DNA data analysis (genomics), secondary and tertiary structure analysis (nucleic acids and proteins), molecular scene analysis, evolutionary trees (phylogenetics), and computing with DNA. The course will consist of introductory lectures by the course coordinators, lectures by invited guests of international repute, and research projects in which inter-disciplinary collaboration between students is encouraged. Given jointly with the School of Computing. 
Three hours per week; lectures and seminars; Winter.   Not offered 2009-2010.
PREREQUISITE: Permission of the department.
EXCLUSION: CISC-875*.
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BCHM-899 Master's Thesis Research
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BCHM-930 Biochemistry Seminar Program for Ph.D. students
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BCHM-999 Ph.D. Thesis Research
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Graduate Studies Courses of Instruction Biochemistry
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