Queen's University : Courses of Instruction

BCHM-102*/0.5	MBIO-218*/0.5	BCHM-310/1.0	BCHM-313*/0.5	BCHM-315*/0.5	BCHM-316*/0.5	BCHM-317*/0.5	BCHM-410*/0.5
BCHM-411*/0.5	BCHM-421/1.0	BCHM-422/1.0	BCHM-432*/0.5	BCHM-441*/0.5	BCHM-442*/0.5

AVAILABILITY

The Department of Biochemistry does not offer all of the courses listed in the Calendar every year. For the most up-to-date information on the availability of courses offered in the current year, check QCARD or consult with the departmental office.

BCHM-102*/0.5

Introduction to Biochemistry

3L;1T

Chemical principles as applied to biochemistry, human and clinical biochemistry. Winter Term.� PREREQUISITE 4U Chemistry. Non-nursing students require permission of the Department.

EXCLUSIONS�� BCHM 310, BCHM 315*, BCHM 316*. Not available for BSCH SSP LISC, BSC�GEN BCHM, or BSCH MAJ, SSP, MED BCHM students.

MBIO-218*/0.5

Gene Structure and Function (Molecular Biology)

3L;1T alt.wks.

Molecular mechanisms of gene expression, biochemistry of nucleic acids, chromatin structure, DNA replication, RNA transcription, processing and translation in prokaryotic, eukaryotic and viral systems. Offered jointly by the Departments of Biochemistry, Biology and Microbiology and Immunology. Winter Term. PREREQUISITE�� BIOL 205*.

EXCLUSION MBIO 318*.

BCHM-310/1.0

General Biochemistry

3L;3P alt.wks.

Principles of biochemistry. Individual topics are described under BCHM 315* and BCHM 316*. Laboratory every other week. Enrolment will be limited because of laboratory constraints, and selection will be based on academic standing. PREREQUISITE�� MBIO 218* and CHEM 222* and CHEM 223* for BCHM students, or CHEM 281* and CHEM 282* for LISC and BMCO students; and third-year standing in concentration. Third-year BCHM students lacking CHEM 222*, or LISC and BMCO students lacking CHEM 282*, may take them as a corequisite with permission of the Department.

EXCLUSIONS�� BCHM 102*, BCHM 315*, BCHM 316*.

BCHM-313*/0.5

Physical Biochemistry

The application of physical chemistry to biological problems, with an emphasis on arithmetical and algebraic manipulation. Topics include enzyme kinetics, bioenergetics, centrifugation, radioactivity and spectroscopy. Winter Term. PREREQUISITE�� None. BCHM 310, or BCHM 315* and BCHM 316* and a solid background in physical, analytical and organic chemistry are recommended.

BCHM-315*/0.5

Proteins and Enzymes

Principles of protein biochemistry, enzymology, and protein engineering. Fall Term. PREREQUISITE�� MBIO 218* and CHEM 222* and CHEM 223* for BCHM students, or CHEM 281* and CHEM 282* for LISC and BMCO students; and third-year standing in concentration. Third-year BCHM students lacking CHEM 222*, or LISC and BMCO students lacking CHEM 282*, may take them as a corequisite with permission of the Department.

EXCLUSIONS�� BCHM 102*, BCHM 310.

BCHM-316*/0.5

Metabolism

Metabolism of carbohydrates, amino acids and lipids. Role of coenzymes. Generation and storage of metabolic energy. Principles of regulatory mechanisms, membrane structure and function, hormone action, and cellular signalling. Winter Term. PREREQUISITE�� BCHM 315*.

EXCLUSIONS�� BCHM 102*, BCHM 310.

BCHM-317*/0.5

Introductory Biochemistry Laboratory

Application of separation and assay techniques to the study of proteins, metabolism and molecular biology. Attendance required in both terms. Enrolment will be limited because of laboratory constraints, and selection will be based on academic standing. PREREQUISITES OR COREQUISITES�� BCHM 315* and BCHM 316*.

EXCLUSIONS�� BIOL 304*, BIOL 404*.

REGISTRATION IN�400-LEVEL COURSES

Registration in 400-level courses is limited. Students will be selected based on academic standing and importance of the course to their degree program.

BCHM-410*/0.5

Protein Structure and Function

This course presents an integrated approach to the study of protein function. Topics include proteomic techniques, mass spectrometry, protein purification, imaging, surface plasmon resonance, calorimetry, bioinformatics and protein evolution, protein modifications and processing, interpretation and applications of 3-D structure, and structure-function relationships.�

NOTE�� Offered jointly with BCHM 810*.�Fall Term.

PREREQUISITE�� BCHM 310, or BCHM 315* and BCHM 316* and BCHM 317* for BCHM students; BCHM 310, or BCHM 315* and BCHM 316* for LISC students;�BMCO students contact the Department.�

BCHM-411*/0.5

Advanced Molecular Biology

3L/T

This course concentrates on the molecular biology of mammalian models particularly mechanisms involved in human diseases. The human genome project,�forensic analysis, DNA diagnostics of human diseases, models of transcriptional and growth regulation and cancer, DNA repair, RNA processing and translation are all discussed. Emphasis on recent findings and course materials will be drawn from current reviews.�Winter Term. PREREQUISITE�� MBIO 218* (or MBIO 318*) and either BCHM 310, or BCHM 315* and BCHM 316* and BCHM 317* for BCHM students; MBIO 218* (or MBIO 318*) and either BCHM 310, or BCHM 315* and BCHM 316* for LISC students; BMCO students contact the Department.

BCHM-421/1.0

Advanced Biochemistry Laboratory I

12P

Biochemical research techniques with emphasis on nucleic acids, protein structure and function, regulation of gene expression and metabolic control processes. 1.0-credit course offered in the Fall Term. Enrolment may be limited.

PREREQUISITES�� BCHM 315* and BCHM 316* and BCHM 317*, or BCHM 310, admission to the fourth-year Honours SSP program and permission of the Department.�

BCHM-422/1.0

Advanced Biochemistry Laboratory II

12P

An independent research project by each student in one of the departmental research labs. Evaluation is based on oral presentation, lab performance and a thesis. 1.0-credit course offered in the Winter Term. PREREQUISITE�� BCHM 421.

BCHM-432*/0.5

The Molecular Basis of Cellular Function

Principles of regulatory mechanisms; regulation of cellular function and growth by oncogenes, growth factors, isoprenoids and steroid hormones. Receptors, second messengers and protein phosphorylation.�Correlation of cell ultrastructure with biochemical function. Description of the components, assembly, metabolism and evolution of cellular structures are described. Fall Term. PREREQUISITES�� BCHM 310, or BCHM 315* and BCHM 316* and BCHM 317* for BCHM students; BCHM 310, or BCHM 315* and BCHM 316* for LISC students.

EXCLUSIONS BCHM 431* and BCHM 433*.

BCHM-441*/0.5

Current Topics in Biochemistry

3T/S/P

NOTE�� Honours SSP BCHM students registered in BCHM 421 and BCHM 422 will not be allowed to register in BCHM 441*; Honours SSP LISC students registered in one of ANAT 499, CANC 499, EPID 499, LISC 499, MICR 455, MICR 499, NSCI 499, PATH 499, PHAR 499 or PHGY 499 will not be allowed to register in BCHM 441*.

PREREQUISITES�� BCHM 315*, BCHM 316* and BCHM 317* (or BCHM 310), admission to the final-year Honours Biochemistry major program and permission of the Department.

BCHM-442*/0.5

Seminars in Biochemistry

3T/S/P

Tutorials, assignments and demonstrations in important subjects in biochemistry emphasizing topics of broad interest. Particular emphasis will be paid to the applications of biochemical knowledge and new technologies. Winter Term.
NOTE�� Honours MAJ BCHM students registered in BCHM 441* will not be allowed to register in BCHM 442*.
PREREQUISITES�� BCHM 315*, BCHM 316* and BCHM 317* (or BCHM 310), admission to a final-year Honours BCHM SSP program and permission of the Department.

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