The following courses will be offered in the graduate program.
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QACS-799*  |
Introduction to Animal Care |
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This non-credit WebCT course is entirely online and self-directed. It is offered every semester and is obligatory for all students undertaking research, teaching or testing involving the use of vertebrate animals. It should be taken before any animal work is begun. The course will cover ethical and legal obligations related to the use of animals; standards of care; sources of animals; how health and disease affect research data; humane endpoints; principles of anesthesia and recovery surgery. Students need to take this seminar only once. Students who passed LISC-488 are exempt from QACS 799. Exclusions: LISC-488. Every semester; Moodle; Animal Care Service; Course Registration Contact:Karoline Machado email machadok@queensu.ca
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| BCHM-810* |
Protein Structure and Function |
3L/T |
This course presents an integrated approach to the study of protein function. Topics include proteomic techniques in protein profiling, mass spectrometry, 2-D gel electrophoresis, yeast 2-hybrid analysis, protein chips, protein purification, imaging, surface plasmon resonance, calorimetry, bioinformatics and protein evolution, protein modifications and processing, interpretation and applications of 3-D structure, protein structure-function relationships. Three lecture hours per week; Fall. A. Mak. Offered jointly with BCHM-410* with additional work required.
PRE-REQUISITES: BCHM-310 or 315*/316*/317* or permission of the instructor.
EXCLUSION: BCHM-410*
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| BCHM-811* |
Advanced Molecular Biology |
3L/T |
This course concentrates on the molecular biology of mammalian models particularly mechanisms involved in human diseases. The human genome project, forensic analysis, DNA diagnostics of human diseases, models of transcriptional and growth regulation and cancer, DNA repair, RNA processing and translation are all discussed. Emphasis on recent findings and course materials will be drawn from current reviews.
Three lecture hours per week. Winter. C. Mueller. Offered jointly with BCHM-411* with additional work required.
PREREQUISITE: BCHM-310 or 315*/316*/317* or permission of the instructor
EXCLUSION: BCHM-411*.
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| BCHM-820* |
Advanced Topics in Molecular Biology |
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Discussions and presentations on current topics in molecular biology. The emphasis will be on mammalian systems and will cover a wide range of topics relating to recent advances in molecular biology. Typical topics include gene regulation, replication, DNA repair, forensic analysis, human genomics and genetics. Marks are based on student presentations and essays typically in "News and Views" or Mini-Review formats. Three hours per week, presentations and discussions of original papers. Fall; Alternate years; C. Mueller. Not offered 2011-2012.
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| BCHM-822* |
Mechanisms of Metabolic Control |
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Lectures and discussions on mechanisms of metabolic control. Recent research on a wide range of specific metabolic systems is examined critically. Emphasis is placed on biochemical factors and principles which play a role in the integration and control of metabolism.
Lectures and seminars, three hours per week; Winter; G.P.Côté. Offered 2011-2012.
PREREQUISITE: BCHM-431* or equivalent.
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| BCHM-823* |
Advances in Protein Structure and Function |
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This course consists of weekly presentations and discussions of recent advances towards the understanding of protein structure and function. Topics of discussion include novel approaches, techniques and concepts in the discovery of protein functions. Students will develop skills in literature research, critical evaluation of published work, effective presentation and discussion of papers.A specific theme, such as cell motility, may be used to illustrate research approaches employed to study biological systems in general. Three lecture hours per week; Winter; Alternate years; A. Mak. Not offered 2011-2012.
PREREQUISITE: BCHM-410* or equivalent.
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| BCHM-824* |
Topics in Biophysical Chemistry |
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This course will consist of seminars and lectures generally based on topics such as equilibrium binding, enzyme kinetics, hydrodynamics and spectroscopy. Protein structure determination using methods such as x-ray crystallography and protein NMR will be covered. Specific emphasis will be placed on topics related to the interests and research projects of the students taking the course. The course will include a practical component involving hands-on experience with state of the art physical biochemical tools. This component will require 15-20 hours of the students time.Three lecture hours per week; Fall. Not offered 2011-2012.
PREREQUISITE: BCHM-313 or its equivalent.
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| BCHM-828*/928* |
Research Project in Biochemistry |
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This course is intended to provide the student with the opportunity to gain familiarity with their research field. Students will review the literature related to their proposed graduate research thesis project and write a series of essays on topics selected in consultation with their supervisor; these will be evaluated by a supervisory committee consisting of their supervisor and two other faculty members. They will also develop a written draft research proposal that will be presented to their supervisory committee and defended in a final oral examination. This course is not mandatory but is highly recommended to be taken by students in the first full term of the graduate program. G.P. Côté (course coordinator).
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| BCHM-830 |
Biochemistry Seminar Program for M.Sc. students |
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| BCHM-832* |
Molecular Basis of Cell Function |
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This course provides an introduction to the signaling pathways that regulate key cellular functions such as growth and motility. The biochemical and structural principles that underlie the regulation of enzyme and protein activity in cells are emphasized. Topics include protein kinases and phosphatases, ubiquitin modification, G-protein-coupled receptors, growth factor receptors, scaffold and adaptor proteins, Ras GTPases, phospholipases, oncogenes, cyclic nucleotides, phosphoinositides, isoprenoids and steroid hormones. Offered jointly with BCHM 432. Three lecture hours per week. Fall; G.P. Côté.
PREREQUISITE: BCHM 310, or BCHM 315 and BCHM 316 and BCHM 317 for BCHM students; BCHM 310, or BCHM 315 and BCHM 316 for LISC students (or equivalent).
EXCLUSION: BCHM432 (BCHM 431,BCHM 433, BCHM 831* and BCHM 833*).
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| BCHM-841* |
Current Topics in Biochemistry I |
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This course will focus on protein structure and function with special emphasis on membrane proteins and selected soluble protein systems. The course will consist of lectures and presentations that will be organized around specific readings from the recent literature. A portion of the course will be devoted to membrane protein structure and function. Selected examples of structural and functional studies of soluble proteins will include enzymes and inhibitors; protein-protein interactions; protein engineering; high-throughput identification of enzyme substrates. Some instruction will be given in homology modeling and database analysis of gene products. Three hours per week, half course lectures and seminars. Fall; Alternate years; B. Hill, P. Davies. Offered 2011-2012.
Prerequisite: BCHM 410* and BCHM 411* (or equivalent) and permission of co-ordinator.
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| BCHM-875* |
Bioinformatics |
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This inter-disciplinary course, designed for students in the computational and life sciences, looks at the application of computing concepts and techniques to problems in molecular biology. It demonstrates the application of a variety of computational tools for the analysis and understanding of molecular sequence and structure data. Topics may include: DNA data analysis (genomics), secondary and tertiary structure analysis (nucleic acids and proteins), molecular scene analysis, evolutionary trees (phylogenetics), and computing with DNA. The course will consist of introductory lectures by the course coordinators, lectures by invited guests of international repute, and research projects in which inter-disciplinary collaboration between students is encouraged. Given jointly with the School of Computing.
Three hours per week; lectures and seminars; Winter. Not offered 2011-2012.
PREREQUISITE: Permission of the department.
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| BCHM-930 |
Biochemistry Seminar Program for Ph.D. students |
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Courses of Instruction 
