Related to the textbook, we cover the following topics.

1. Chapter 4: DNA, Chromosomes and Genomes.  In this chapter we cover the details of DNA structure,  chromatin remodeling, chromatin structure
2. Chapter 5: DNA replication, repair and recombination. We focus primarily on the process of replication including telomeres, as well as recombination and repair.
3. Chapter 6: How cells read the genome: from DNA to protein. We cover this chapter in great detail including transcription, translation, as well as the role of small RNAs in gene regulation. It is expected that you know the basics of transcription and translation before you take this course, we will link transcription and translation to protein function and localisation.
4. Chapter 7: Control of Gene Expression. Presented in combination with Chapter 2 we cover the regulation of transcription and translation as well as post-transcriptional and post-translation regulation.
5. Chapter 8: Manipulating proteins, DNA and RNA. We discuss many methods including cell culture, purification of nucleic acid and proteins, analysis and manipulation of DNA, studying gene expression by northern blot, microarrays and serial analysis of gene expression.
6. Chapter 10 and 11: Membrane Structure and membrane transport. We cover the typical structure of the membrane and how proteins embedded in the membrane can control the influx and efflux of ions, proteins etc.
7. Chapter 12: Intracellular compartmental and protein sorting and Chapter 13 Intracellular Vesicular Traffic. We cover this topic in detail, specifically looking at the mechanisms of getting proteins to the nucleus, mitochondria, ER, golgi, cell membrane, lysosome etc. Movement of proteins via vesicles is covered in detail.
8. Chapter 14: Energy Conversion: Mitochondria and Chloroplasts. We mostly cover the origin of mitochondria and how these create energy in the eukaryotic cell.
9. Chapter 15: Mechanisms of Cell Communication. We discuss the many mechanisms of cell-cell communication and the signal transduction pathways that are responsible for this communication.
10. Chapter 16: Cytoskeleton. We study the assembly and function of the cytoskeleton.
11. Chapter 17: The Cell Cycle. We briefly discuss the cell cycle and the proteins that are responsible for this process.
12. Chapter 18: Cell Junctions, Cell Adhesions, and the Extracellular Matrix. We cover this chapter in detail with a specific emphasis on the connections between gut epithelial cells, basal lamina, and the role of specific cell surface proteins such as integins. We also discuss the plant cell wall.
13. Chapter 18: Apoptosis. We briefly discuss apoptosis, the signal transduction pathway leading to programmed cell death, the role of Bcl1 and caspases in emphasized.
14. Cell Differentiation:  As an example of cell differentiation we may look at the development of muscle cells. Each year we use a different example.

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More information:

• Computer Requirements and Internet Access
• Moodle, Our Online Learning Environment 
• Academic Integrity
• Evaluation
• Suggested Time Commitment
• Required Material