Department of Physics, Engineering Physics & Astronomy

Department of Physics, Engineering Physics & Astronomy
Department of Physics, Engineering Physics & Astronomy

Investigating Bioactive Calcium Phosphates

Malcolm Stott
Department of Physics, Queen's University

Wednesday, April 7, 2004
1:30 PM @ Stirling A

Abstract:

A Si-doped calcium phosphate sintered at about 1000C produces a ceramic material which exhibits unique bioactivity. This inorganic material, marketed by Millenium Biologix Inc. as Skelite, actively participates in the body's natural process of bone remodeling being fully resorbed and replaced in time by natural bone. It is used clinically in bone repair.

Properties of this complex material and the origin of its bioactivity are difficult to study e.g. it is a mixture of several calcium phosphate phases. A team consisting of Mike Sayer and myself, postdocs and students, along with Millenium Biologix, is using a combination of experiment and theory to investigate the material and its bioactivity. A variety of experimental tools such as x-ray diffraction, NMR, infrared absorption, have been brought to bear on this problem, supplemented by first principles materials simulation. We have come to regard the so-called ab initio simulations as simply one more tool for deciphering the workings of this material. I'll describe the properties of the material, some of the simulations and the progress we have made in understanding it.

Refreshments will be available after the talk.