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Queen's University

Stress, Neurodevelopment & Emotions Lab


Since 2010

Nunes, M.L., Khan, R.L., Gomes Filho, I.,Booij, L., Da Costa, J.C.(2013) Maturational changes of neonatal electroencephalogram: A comparison between intra uterine and extra uterine development. Clinical Neurophysiology. In press

Booij, L., Wang, D., Lévesque, M.L.,Tremblay, R.E, Szyf, M.(2013). Looking beyond the DNA Sequence: the Relevance of DNA Methylation Processes for the Stress-Diathesis Model of Depression. Phil Transactions of the Royal Society B. Feb 25. [Epub ahead of print]

Pingault, J.B., Côté, S.M., Booij, L., Ouellet-Morin, I., Castellanos-Ryan, N., Vitaro, F., Turecki, G., Tremblay, R.E. (2013). Age-dependent Effect of the MAOA Gene on Childhood Physical Aggression. Molecular Psychiatry, 18, 1151-1152

Santos, K., Palmini, A., Radziuk, A.L., Rotert, R., Bastos, F., Booij, L., Fernandes, B.S. (2013). The impact of methylphenidate on seizure frequency and severity in children with ADHD and difficult-to-treat epilepsies. Developmental Medicine and Child Neurology, 55,654-60.

Verhoeven, F.E.A., Booij, L., Kruijt, A.W., Cerit, H., Antypa, N., Van der Does, A.J.W.(2013). Erratum: The effects of MAOA genotype, childhood trauma and gender on trait and state-dependent aggression. Brain & Behavior, Jan;3(1):42.

Nagano-Saito, A., Dagher, A., Booij, L., Gravel, P., Welfeld, K., Casey, K., Leyton, M., Benkelfat, C (2013). Stress-induced dopamine release in human medial prefrontal cortex: an 18F-Fallypride / PET study in healthy volunteers. Synapse, 2013, in press.

Kruijt, A., Antypa, N., Booij, L., de Jong, P.J., Glashouwer, K., Penninx, B.M.J. Van der Does, A.J.W.(2013). Cognitive reactivity, implicit associations, and the incidence of depression: a two year prospective study. Plos One, 8(7), Jul 26;8(7):e70245. doi: 10.1371/journal.pone.0070245.

Hernaus, D., Collip, D., Lataster, J., Ceccarini, J., Kenis, G., Booij. L., Pruessner, J., Van Laere, K., van Winkel, R., van Os, J., Myin-Germeys. I. (2013) COMT Val(158)Met Genotype Selectively Alters Prefrontal [(18)F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge. PLoS One. 2013 Jun 14;8(6):e65662. doi: 10.1371/journal.pone.0065662.

Lataster, J., Collip, D., Hernaus, D., Ceccarini, J., Haas, D., Booij, L., Van Os, J., Pruessner, J., Van Laere, K., Myin-Germeys, I. (2013). Familial liability to psychosis is associated with aberrant dopamine stress signaling in ventromedial prefrontal cortex. Schizophrenia Bulletin, Jan 30 [Epub ahead of print].

Hemb, M., Palmini, A., Paglioli, E., Beck Paglioli, E., Costa da Costa, J., Azambuja, N., Portuguez, M., Viuniski, V., Booij, L., Nunes, M.L. (2013). Epilepsy surgery for hippocampal sclerosis: an 18 year longitudinal study on future seizure risk. Journal of Neurology, Neurosurgery and Psychiatry, Feb 13 [Epub ahead of print].

Booij, L., Turecki, G., Leyton, M., Gravel, P., Lopez De Lara, C., Diksic, M. & Benkelfat, C. (2012). Polymorphic Variants in the TPH2 Gene Predict Brain Serotonin Synthesis in Humans. Molecular Psychiatry, 17, 809-817.

Booij, L., Benkelfat, C., Leyton, M., Vitaro, F., Gravel, P., Levesque, M.L., Arseneault, L., Diksic, M., Tremblay, R.E. (2012). Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study,Eur Neuropsychopharmacology, 22, 419-423.

Caramaschi, D., Booij, L., Petitclerc, A., Boivin, M., Tremblay, R.E. (2012). Genetic and environmental contributions to saliva testosterone levels in male and female infant twins. Psychoneuroendocrinology, 12, 1954-1959.

Wang, D., Szyf, M., Benkelfat, C., Provençal, N., Turecki, G., Caramaschi, D., Côté, S.M., Vitaro, F., Tremblay, R.E, Booij, L. (2012). Peripheral SLC6A4 DNA Methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PlosOne, Epub 2012 Jun 20.

Verhoeven, F.E.A., Booij, L., Kruijt, A.W., Cerit, H., Antypa, N., Van der Does, A.J.W.(2012) The effects of MAOA genotype, childhood trauma and gender on trait and state-dependent aggression. Brain & Behavior, 2, 806-13.

Van Steenbergen, H., Booij, L., Band, G.P.H., Hommel, B., Van der Does, A.J.W. (2012). Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion. Cognitive, Affective and Behavioral Neuroscience, 12, 280-286

Lataster, J. Collip, D. Ceccarini, J., Haas, D., Booij, L., Van Os, J., Pruessner, J.,  Van Laere, K., Myin-Germeys, I.(2011) Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: A positron emission tomography study using [(18)F]fallypride. Neuroimage, 58(4):1081-9.

Lévesque M.L., Beauregard M., Fortier E., Tremblay R.E., Brendgen M., Pérusse D., Dionne G., Robaey P., Vitaro F., Boivin M., Booij L. (2011). Altered patterns of fronto-limbic activation in children with familial risk of depression. Journal of Affective Disorders, 135, 410-413.

Verhoeven F.E.A., Booij L., Van der Wee N.J.A., Penninx B.W.H.J., Van der Does A.J.W. (2011). Clinical and Physiological Correlates of Irritability in Depression: Results from the Netherlands Study of Depression and Anxiety (NESDA). Depression Research and Treatment, vol. 2011, Article ID 126895, 9 pages, 2011. doi:10.1155/2011/126895.

Booij, L., Tremblay, R.E., Leyton, M., Seguin, J.R., Vitaro, F., Gravel, P., Perreau-Linck, E., Levesque, M., Durand, F., Diksic, M., Turecki, G., & Benkelfat, C (2010). Brain serotonin synthesis in adult males characterized by physical aggression in childhood: A 21 year longitudinal study. PLoSONE, 5(6):e11255.

Booij, L., Van der Does, A.J.W (2010). Emotional processing as a predictor of symptom change: an acute tryptophan depletion study in depressed patients. European Neuropsychopharmacology, 21, 379-383.


Before 2010

Merens, W., Booij, L., Haffmans, P. M. J., & Van der Does, A. J. W. (2008). The effects of experimentally lowered serotonin function on emotional information processing and memory in remitted depressed patients. Journal of Psychopharmacology, 22, 653-62.

Sibon, I., Benkelfat, C. Gravel, P., Aznavour, N. Mzengeza, S., Booij, L., Baker, G., Soucy, J. P., Zimmer, L. Descarries, L. (2008). Decreased Binding of [18F]MPPF in the Dorsal Raphe Nucleus (DRN) of healthy volunteers in response to a single dose of fluoxetine. Biological Psychiatry, 63, 1135-40. 

Sibon, I., Strafella, A. P., Gravel, P., Ko, J. H., Booij, L., Soucy, J. P., Leyton, M., Diksic, M., & Benkelfat, C. (2007). Acute prefrontal cortex TMS in healthy volunteers: effects on brain [11C]-aMtrp trapping. NeuroImage, 34, 1658-64.

Booij, L., & Van der Does, A. J.W. (2007). Cognitive and Serotonergic Vulnerability to Depression: Convergent Findings. Journal of Abnormal Psychology, 116, 86-94.

Leyton, M., aan het Rot, M., Booij, L., Baker, G. B., Young, S. N., & Benkelfat, C. (2007). Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion. J. of Psychiatry and Neuroscience, 32, 129-36.

Boileau, I., Dagher, A., Leyton, M., Welfeld, K., Booij, L., Diksic, M., & Benkelfat, C (2007). Conditioned Dopamine Release in Humans: A PET [11C] raclopride study with Amphetamine.J. of Neuroscience, 27, 3998-4003. 

Merens, W. Booij, L., & Van der Does, A. J. W. (2007). Residual cognitive impairments in remitted depressed patients. Depression and Anxiety, 25, E27-36.

Booij, L., Swenne, C. A., Brosschot, J. F., Haffmans, P. M. J., Thayer, J. F., & Van der Does, A. J. W. (2006).  Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation. Biological Psychiatry, 60, 507-514. 

Booij, L., Merens, W., Markus C. R., & Van der Does, A. J. W. (2006). Diet rich in a-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls. Journal of Psychopharmacology, 20, 526-535.

Van der Does, A. J. W., & Booij, L. (2005). Cognitive therapy does not prevent a response to tryptophan depletion in patients treated with antidepressants. Biological Psychiatry, 58, 913-915.

Booij, L., Van der Does, A. J. W, Haffmans, P. M. J, & Riedel, W. J. (2005). Acute tryptophan depletion in depressed patients treated with a selective serotonin-noradrenalin reuptake inhibitor: augmentation of antidepressant response? Journal of Affective Disorders, 86, 305-311.

Booij, L., Van der Does, A. J. W., Haffmans, P. M. J, Riedel, W. J, Fekkes, D., & Blom, M. J. B. (2005). The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients. Journal of Psychopharmacology, 19, 267-275.

Booij, L., Van der Does, A. J. W, Haffmans, P. M. J, Spinhoven, Ph., & McNally, R. J. (2005). Acute tryptophan depletion as a model of depressive relapse: behavioural specificity and ethical considerations. British Journal of Psychiatry, 187, 148-154.

Booij, L., & Van der Does, A. J.W. (2005). Tryptofaan-depletie als experimenteel model voor depressie [Tryptophan depletion as experimental model for depression]. Neuropraxis, 4, 93-98.

Merens, W., Booij, L., Markus, C.R., Zitman, F.G., Onkenhout, W., & Van der Does, A.J.W. (2005). The effects of a tryptophan-enriched diet on mood and cortisol response in unmedicated recovered depressed patients and controls. British Journal of Nutrition, 94, 415-22.

Booij, L. (2005). Experimental manipulations of tryptophan: insight into depression. PhD. Thesis Leiden University, the Netherlands. Optima publishers, Rotterdam, the Netherlands. ISBN: 90-9019104-6, 316 pages.

Booij, L., Van der Does, A. J. W, & Riedel, W. J. (2003). Monoamine depletion in psychiatric and healthy populations: review. Molecular Psychiatry, 8, 951-973.

Booij, L., Van der Does, A. J. W, Benkelfat, C., Bremner, J. D., Cowen, P. J., Fava, M., Gillin, C., Leyton, M., Moore, P., Smith, K. A., & Van der Kloot, W. A. (2002). Predictors of mood response to acute tryptophan depletion: a reanalysis. Neuropsychopharmacology, 27, 852-861.

Sobczak, S., Riedel, W. J., Booij, L., Aan het Rot, M., Deutz, N. E. P., & Honig, A. (2002). Cognition following acute tryptophan depletion: differences between first-degree relatives of bipolar disorder patients and matched healthy control volunteers. Psychological Medicine, 32, 503-515.

De Waard, D., Brookhuis, K.A., Pernot, L. M.C., Lamers, C.T.J.,Booij, L., Sikkema, K. L., Muntjewerff, N.D., Vuurman, E.F.P.M., & Riedel, W.J.(2000). Een onderzoek naar de effecten van MDMA (Ecstasy) op cognitieve- en psychomotorische functies, rijgedrag in de rijsimulator, en consequenties voor de verkeersveiligheid [A study into the effects of MDMA on cognitive, psychomotor and driving simulator performance and consequences for traffic safety]. COV 2000-06. Centrum voor Omgevings- en Verkeerspsychologie, Rijksuniversiteit Groningen, Groningen.

Kingston, Ontario, Canada. K7L 3N6. 613.533.2000