PAPERS

    2015

  1. Mahler DA, O’Donnell DE. Recent advances in dyspnea. Chest 2015; 147(1): 232-241.

  2. Faisal A, Webb KA, Guenette JA, Jensen D, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Effect of age-related ventilatory inefficiency on respiratory sensation during exercise. Respir Physiol Neurobiol 2015; 205: 129-139.

  3. Medeiros WM, Fernandes MCT, Azevedo DP, de Freitas FFM, Amorim BC, Chiavegato LD, Hirai DM, O’Donnell DE, Neder JA. Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD: peripheral factors. Am J Physiol Regul Integr Comp Physiol 2015; 308: R105-R111.

  4. Oliveira MF, Zelt JT, Jones JH, Hirai DM, O’Donnell DE, Verges S, Neder JA. Does impaired O2 delivery during exercise accentuate central and peripheral fatigue in patients with coexistent COPD-CHF? Front Physiol 2015; 5: 514.

  5. Neder JA, Arbex FF, Alencar MC, O’Donnell CD, Cory J, Webb KA, O’Donnell DE. Exercise ventilatory inefficiency in mild to end-stage COPD. Eur Respir J 2015; 45(2): 377-387.

  6. Green ME, Natarajan N, O’Donnell DE, Williamson T, Kotecha J, Khan S, Cave A. Chronic obstructive pulmonary disease in primary care: an epidemiologic cohort study from the Canadian Primary Care Sentinel Surveillance Network. Can Med Assoc J Open 2015; 3(1): E15-22.

  7. Neder JA, Ramos RP, Ota-Arakaki JS, Hirai DM, D’Arsigny CL, O’Donnell DE. Exercise intolerance in pulmonary arterial hypertension: the role of cardiopulmonary exercise testing. Ann Am Thorac Soc 2015; 12(4): 604-612.

  8. Gagnon P, Casaburi R, Saey D, Porszasz J, Provencher S, Milot J, Bourbeau J, O’Donnell DE, Maltais F. Cluster analysis in patients with GOLD 1 chronic obstructive pulmonary disease. PLoS One 2015; 10(4): e0123626.

  9. Neder JA, Langer D, Ciavaglia C, Webb K, O’Donnell C, Cory J, O’Donnell DE. Ventilation distribution heterogeneity at rest as a marker of exercise impairment in mild to advanced COPD. COPD published online September 17, 2014 as doi: 10.3109/15412555.2014.948997

  10. Elbehairy A, Raghavan N, Cheng S, Yang L, Webb KA, Neder JA, Guenette JA, Mahmoud MI, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Physiological characterization of the chronic bronchitis phenotype in GOLD grade 1B COPD. Chest published online November 13, 2014 as doi: 10.1378/chest.14-1491

  11. Vozoris NT, O’Donnell DE. Smoking, activity level and exercise test outcomes in a young population sample without cardio-pulmonary disease. J Sports Med Phys Fitness published online January 22, 2015 [PMID: 25611081]

  12. Elbehairy AF, Ciavaglia CE, Webb KA, Guenette JA, Jensen D, Mourad SM, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Pulmonary gas exchange abnormalities in mild COPD: implications for exercise intolerance. Am J Respir Crit Care Med published online March 31, 2015 as doi: 10.1164/rccm.201501-0157OC

  13. 2014

  14. Bourbeau J, Tan WC, Benedetti A, Aaron SD, Chapman KR, Coxson HO, Cowie R, Fitzgerald M, Goldstein R, Hernandez P, Leipsic J, Maltais F, Marciniuk D, O’Donnell D, Sin DD; for the CanCOLD study group. Canadian cohort obstructive lung disease (CanCOLD): fulfilling the need for longitudinal observation studies in COPD. COPD 2014; 11(2): 125-32. [PDF]

  15. O’Donnell DE, Laveneziana P, Webb K, Neder JA. Chronic obstructive pulmonary disease: clinical integrative physiology. Clin Chest Med 2014; 35(1): 51-69. [PDF]

  16. Cortés-Telles A, Forkert L, O’Donnell DE, Moran-Mendoza O. Idiopathic pulmonary fibrosis: new insights on functional characteristics at diagnosis. Can Respir J 2014; 21(3): e55-60. [PDF]

  17. O’Donnell DE, Maltais F, Porszasz J, Webb KA, Albers FC, Deng Q, Iqbal A, Paden HA, Casaburi R; on behalf of the 205.440 study group. The continuum of physiological impairment during treadmill walking in patients with mild-to-moderate COPD: patient characterization phase of a randomized clinical trial. Plos One 2014; 9(5):e96574. [PDF]

  18. Laveneziana P, Webb KA, Wadell K, Neder JA, O’Donnell DE. Does increased expiratory muscle activity contribute to dyspnea during exercise in COPD? Respir Physiol Neurobiol 2014; 199C: 24-33. [PDF]

  19. Tan W, Bourbeau J, Hernandez P, Chapman KR, Cowie R, Fitzgerald JM, Marciniuk DD, Maltais F, Buist AS, O’Donnell DE, Sin DD, Aaron S; for the CanCOLD Collaborative Research Group. Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: results from a population-based study. Thorax 2014; 69(8): 709-717. [PDF]

  20. O’Donnell DE, Ciavaglia CE, Neder JA. When obesity and COPD collide: physiological and clinical consequences. Ann Am Thorac Soc 2014; 11(4): 635-644. [PDF]

  21. Ciavaglia CE, Guenette JA, Ora J, Webb KA, Neder JA, O’Donnell DE. Does exercise test modality influence perceived dyspnoea in obese patients with COPD? Eur Respir J 2014; 43(6): 1621-1630. [PDF]

  22. O’Donnell DE, Gebke KB. Activity restriction in mild COPD: a challenging clinical problem. Int J COPD 2014; 9: 577-588. [PDF]

  23. Tan WC, Bourbeau J, O’Donnell D, Aaron S, Maltais F, Marciniuk D, Hernandez P, Cowie R, Chapman K, Buist SA, Sin D, Fitzgerald M; CanCOLD Collaborative Research Group. Quality assurance of spirometry in a population-based study – predictors of good outcome in spirometry testing. COPD 2014; 11(2): 143-151. [PDF]

  24. Guenette JA, Chin RC, Cheng S, Dominelli PB, Raghavan N, Webb KA, Neder JA, O’Donnell DE. Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade 1 COPD. Eur Respir J 2014; 44(5): 1177-1187.

  25. Langer D, Ciavaglia CE, Neder JA, Webb KA, O’Donnell DE. Lung hyperinflation in COPD: mechanisms, clinical implications and treatment. Expert Rev Respir Dis 2014; 8(6): 731-749.

  26. O’Donnell DE, Gebke KB. Examining the role of activity, exercise, and pharmacology in mild COPD. Postgrad Med 2014; 126(5): 135-145.

  27. Ciavaglia CE, Guenette JA, Langer D, Webb KA, Neder JA, O’Donnell DE. Differences in respiratory muscle activity during cycling and walking do not influence dyspnea perception in obese patients with COPD. J Appl Physiol 2014; 117(11): 1292-1301.

  28. O’Donnell DE. Adult survivors of preterm birth: what spirometry conceals, exercise tests reveal (editorial). Ann Am Thorac Soc 2014; 11(10): 1606-1607.

  29. Casaburi R, Maltais F, Porszasz J, Albers F, Deng Q, Iqbal A, Paden HA, O’Donnell DE; on behalf of the 205.440 investigators. Effect of tiotropium on hyperinflation and treadmill exercise tolerance in mild-moderate chronic obstructive pulmonary disease. Ann Am Thorac Soc 2014; 11(9): 1351-1361.

  30. 2013

  31. Guenette JA, Webb KA and O’Donnell DE. Effect of fluticasone/salmeterol combination on dyspnea and respiratory mechanics in mild-to-moderate COPD. Respir Med 2013; 107: 708-716. [PMID: 23421968] [PDF]

  32. Wadell K, Webb KA, Preston ME, Amornputtisathaporn N, Samis L, Patelli J, Guenette JA, O’Donnell DE. Impact of pulmonary rehabilitation on the major dimensions of dyspnea in COPD>. COPD 2013; 10(4): 425-435. [PMID: 23537344] [PDF]

  33. Guenette JA, Chin RC, Webb KA, O’Donnell DE. Inspiratory capacity during exercise: measurement, analysis and interpretation [review]. Pulm Med 2013; article ID 956081, 13 pages. [PMID: 23476765][PDF]

  34. Thomas M, Decramer M, O’Donnell DE. No room to breathe: the importance of lung hyperinflation in COPD [review]. Prim Care Respir J 2013; 22(1): 101-111. [PMID: 23429861] [PDF]

  35. Tan WC, Bourbeau J, Hernandez P, Chapman KR, Cowie R, Fitzgerald JM, Aaron S, Marciniuk DD, Maltais F, Buist AS, O’Donnell DE, Sin DS. Bronchodilator responsiveness and reported respiratory symptoms in an adult population. PLoS ONE 2013; 8(3): e58932. [PMID: 23554960] [PDF]

  36. Chin RC, Guenette JA, Cheng S, Raghavan N, Amornputtisathaporn N, Cortés-Télles A, Webb KA, O’Donnell DE. Does the respiratory system limit exercise in mild COPD? Am J Respir Crit Care Med 2013; 187(12); 1315-23. (with accompanying editorial by Jerome Dempsey) [PMID: 23590271] [PDF]

  37. Elbehairy AF, Webb KA, Neder JA, O’Donnell DE. Should mild COPD be treated? Evidence for early pharmacological intervention. Drugs 2013; 73(18): 1991-2001 [PMID: 24214364].[PDF]

  38. 2012

  39. O’Donnell DE, Guenette J, Maltais F, Webb K. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea and ventilatory capacity during exercise. Chest 2012; 141(3): 753-762. [PDF]

  40. Jensen D, Alsuhail A, Viola R, Dudgeon DJ, Webb KA, O’Donnell DE. Inhaled fentanyl citrate improves exercise endurance during high-intensity constant-work-rate cycle exercise in chronic obstructive pulmonary disease. J Pain Symptom Manage 2012; 43(4); 706-719. [PDF]

  41. Raghavan N, Lam YM, Webb KA, Guenette JA, Amornputtisathaporn N, Raghavan R, Tan WC, Bourbeau J, O'Donnell DE. Components of the COPD Assessment Test (CAT) associated with a diagnosis of COPD in a random population sample. COPD. 2012 Apr;9(2):175-83. [PDF]

  42. Guenette JA, Diane Lougheed M, Webb KA, O'Donnell DE. Can an 86-year-old woman with advanced lung disease be a world class athlete? Respir Physiol Neurobiol. 2012 Apr 30;181(2):162-6. [PDF]

  43. Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O'Donnell DE; American Thoracic Society Committee on Dyspnea. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012 Feb 15;185(4):435-52. [PDF]

  44. Marciniuk DD, Hernandez P, Balter M, Bourbeau J, Chapman KR, Ford GT, Lauzon JL, Maltais F, O'Donnell DE, Goodridge D, Strange C, Cave AJ, Curren K, Muthuri S; Canadian Thoracic Society COPD Clinical Assembly Alpha-1 Antitrypsin Deficiency Expert Working Group. Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline. Can Respir J. 2012 Mar-Apr;19(2):109-16. Erratum in: Can Respir J. 2012 Jul-Aug;19(4):272. [PDF]

  45. O’Donnell DE, Bredenbröker D, Brose M, Webb KA. Physiological effects of roflumilast at rest and during exercise in COPD. Eur Respir J 2012; 39: 1104-1112. [PDF]

  46. Guenette JA, Webb KA, O’Donnell DE. Does dynamic hyperinflation contribute to dyspnea during exercise in patients with COPD? Eur Respir J 2012; 40(2): 322-329. (with accompanying editorial by Luo, Hopkinson and Polkey). [PDF]

  47. Vozoris NT, O'Donnell DE. Prevalence, risk factors, activity limitation and health care utilization of an obese, population-based sample with chronic obstructive pulmonary disease. Can Respir J. 2012 May-Jun;19(3):e18-24. [PDF]

  48. Bourbeau J, Tan WC, Benedetti A, Aaron SD, Chapman KR, Coxson HO, Cowie R, Fitzgerald M, Goldstein R, Hernandez P, Leipsic J, Maltais F, Marciniuk D, O’Donnell D, Sin DD; for the CanCOLD study group. Canadian cohort obstructive lung disease (CanCOLD): fulfilling the need for longitudinal observation studies in COPD. COPD published online March 20, 2012 as doi:10.3109/15412555.2012.665520 [PDF]

  49. O'Donnell DE, O'Donnell CD, Webb KA, Guenette JA. Respiratory Consequences of Mild-to-Moderate Obesity: Impact on Exercise Performance in Health and in Chronic Obstructive Pulmonary Disease. Pulm Med.2012; 2012: 818925. [PDF]

  50. Laveneziana P, Guenette JA, Webb KA, O'Donnell DE. New physiological insights into dyspnea and exercise intolerance in chronic obstructive pulmonary disease patients. Expert Rev Respir Med. 2012 Dec;6(6): 651-62. [PDF]

  51. 2011

  52. Jensen D, O’Donnell DE. The impact of human pregnancy on perceptual responses to chemoreflex vs. exercise stimulation of ventilation: a retrospective analysis. Respir Physiol Neurobiol 2011; 175(1): 55-61. [PDF]

  53. O’Donnell DE, Deesomchok A, Lam Y-M, Guenette JA, Amornputtisathaporn N, Forkert L, Webb KA. Effects of body mass index on static lung volumes in patients with airway obstruction. Chest 2011; 140: 461-468. [PDF]

  54. Ora J, Laveneziana P, Wadell K, Preston M, Webb KA, O’Donnell DE. Effect of mild obesity on respiratory mechanics during rest and exercise in COPD. J Appl Physiol 2011; 111:10-19. (with accompanying editorial by Johnson and Babb) [PDF]

  55. O’Donnell DE, Casaburi R, Vincken W, Puente-Maestu L, Swales J, Lawrence D, Kramer B; on behalf of INABLE study investigators. Effect of indacaterol on exercise endurance and lung hyperinflation in COPD. Respir Med 2011; 105(7): 1030-1036. [PDF]

  56. Raghavan N, Guenette JA, O’Donnell DE.  The role of pharmacotherapy in mild to moderate chronic obstructive pulmonary disease. Ther Adv Respir Dis 2011; 5(4): 245-54. [PDF]

  57. Raghavan N, Webb KA, Amornputtisathaporn N, O’Donnell DE. Recent advances in pharmacotherapy for dyspnea in COPD. Curr Opin Pharmacol 2011; 11(3): 204-210. [PDF]

  58. Marciniuk DD, Goodridge D, Hernandez P, Rocker G, Balter M, Bailey P, Ford G, Bourbeau J, O’Donnell DE, Maltais F, Mularski RA, Cave AJ, Mayers I, Kennedy V, Oliver TK, Brown C; Canadian Thoracic Society COPD Committee Dyspnea Expert Working Group. Managing dyspnea in patients with advanced chronic obstructive pulmonary disease: A Canadian Thoracic Society clinical practice guideline. Can Respir J 2011; 18(2): 69-78. [PDF]

  59. Guenette JA, Jensen D, Webb KA, Ofir D, Raghavan N, O’Donnell DE. Sex differences in exertional dyspnea in patients with mild COPD:  Physiological mechanisms. Respir Physiol Neurobiol 2011; 177(3): 218-227. [PDF]

  60. O’Meara P, Guenette JA, Raghavan N, Amornputtisathaporn N, deMetz CE, Nolan RL, O’Donnell DE. Mechanisms of dyspnea relief following radiation treatment in a patient with severe COPD. Eur Respir J 2011; 38(3): 728-730. [PDF]

  61. O’Donnell DE, Guenette J, Maltais F, Webb K. Decline of resting inspiratory capacity in COPD:  the impact on breathing pattern, dyspnea and ventilatory capacity during exercise. Chest published online on August 18, 2011 as doi:10.1378/chest.11-0787 [PDF]

  62. Jensen D, Alsuhail A, Viola R, Dudgeon DJ, Webb KA, O’Donnell DE. Inhaled fentanyl citrate improves exercise endurance during high-intensity constant-work-rate cycle exercise in chronic obstructive pulmonary disease.  J Pain Symptom Manage published online on December 12, 2011 as doi:10.1016/j.jpoinsymman.2011.05.007 [PDF]

  63. Jensen D, O’Donnell DE, Li R, Luo Y-M. Effects of dead space loading on neuro-muscular and neuro-ventilatory coupling of the respiratory system during exercise in health: implications for dyspnea and exercise tolerance. Respir Physiol Neurobiol 2011; 179: 219-226. [PDF]

  64. O’Donnell DE, Bredenbröker D, Brose M, Webb KA. Physiological effects of roflumilast at rest and during exercise in COPD. Eur Respir J published online on September 29, 2011 as doi:10.1183/09031936.00096511 [PDF]

  65. Guenette JA, Raghavan N, Harris-McAllister V, Preston ME, Webb KA, O’Donnell DE.  Effect of adjunct fluticasone propionate on airway physiology during rest and exercise in COPD. Respir Med 2011; 105: 1836-1845. [PDF]

  66. Laveneziana P, Webb KA, Ora J, Wadell K, O’Donnell DE. Evolution of dyspnea during exercise in COPD: impact of critical volume constraints. Am J Respir Crit Care Med 2011; 184(12):1367-1373. [PDF]

  67. Raghavan N, Lam Y-M, Webb KA, Guenette JA, Amornputtisathaporn N, Raghavan R, Tan WC, Bourbeau J, O’Donnell DE. Components of the COPD Assessment Test (CAT) associated with a diagnosis of COPD in a random population sample. COPD accepted for publication on December 1, 2011 for printing in April 2012 (vol 9, issue 2).

  68. Guenette JA, Webb KA, O’Donnell DE. Does dynamic hyperinflation contribute to dyspnea during exercise in patients with COPD? Eur Respir J published online December 19, 2011 as doi:10.1183/09031936.00157711 [PDF]

  69. Vozoris N, O’Donnell D. Prevalence, risk factors, activity limitation, and health outcomes of an obese population-based sample with chronic obstructive pulmonary disease. Can Respir J accepted for publication on November 30, 2011.

  70. Tan WC, Bourbeau J, Hernandez P, Chapman K, Cowie R, Fitzgerald M, Aaron S, Marciniuk D, Maltais F, O’Donnell D, Goldstein R, Sin D, Chan-Yeung M, Manfreda J, Anthonisen N, Tate R, Sears M, Siersted H, Becklake M, Ernst P, Bowie D, Sweet L, Van Til L. Canadian prediction equations of spirometric lung function for Caucasian adults 20 to 90 years of age: Results from the Canadian Obstructive Lung Disease (COLD) study and the Lung Health Canadian Environment (LHCE) study. Can Respir J 2011; 18(6): 321-326. [PDF]
  71. 2010

  72. Jensen D, Webb KA, O’Donnell DE. The increased ventilatory response to exercise in pregnancy reflects alterations in the respiratory control system’s ventilatory recruitment threshold for CO2. Respir Physiol Neurobiol 2010; 171(2):75-82. [PDF]

  73. O’Donnell DE. Prioritizing research at the Canadian Thoracic Society and beyond. Can Respir J 2010; 17(1): 9. [PDF]

  74. Ora J, O’Donnell DE. Modern management of chronic obstructive pulmonary disesase. Minerva Pneumologica 2010; 49(1): 1-16. (invited review)

  75. Raghavan N, Ora J, Webb KA, O’Donnell DE. “Mild” COPD – is there a case for earlier treatment? Annals of Respiratory Medicine 2010; 1(1): 23-30. (invited review) [PDF]

  76. Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HL, Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O’Donnell DE, Waller A. American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 2010; 137(3): 674-91. [PDF]

  77. Ora J, Jensen D, O’Donnell DE. Exertional dyspnea in chronic obstructive pulmonary disease: mechanisms and treatment approaches. Curr Opin Pulm Med 2010; 16(2): 144-9. [PDF]

  78. Deesomchok A, Fisher T, Webb K, Ora J, Lam Y-M Lam, Lougheed MD, O’Donnell DE. Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma. Am J Respir Crit Care Med 2010; 181: 125-33. [PDF]

  79. Jensen D, Webb KA, O’Donnell DE. The increased ventilatory response to exercise in pregnancy reflects alterations in the respiratory control system’s ventilatory recruitment threshold for CO2. Respir Physiol Neurobiol 2010; 171(2):75-82. [PDF]

  80. Laviolette L, Sava F, O’Donnell DE, Webb KA, Hamilton AL, Kesten S, Maltais F. Effect of obesity on constant workrate exercise in hyperinflated men with COPD. BMC Pulm Med 2010; 10: 33. [PDF]

  81. O’Donnell DE, Ora J.  The impact of obesity on dynamic respiratory mechanics, dyspnea and exercise tolerance in COPD.  Can Respir J 2010; 17(A): 30A-31A. [PDF]

  82. O’Donnell DE, Ora J, Laveneziana P. Clinical benefits of maximal bronchodilation in chronic obstructive pulmonary disease (Part I). Hot Topics in Respiratory Medicine 2010; 12: 25-32. [PDF]

  83. Marciniuk DD, Brooks D, Butcher S, Debigare R, Dechman G, Ford G, Pepin V, Reid D, Sheel AW, Stickland MK, Todd DC, Walker SL, Aaron SD, Balter M, Bourbeau J, Hernandez P, Maltais F, O’Donnell DE, Bleakney D, Carlin B, Goldstein R, Muthuri SK; the CTS COPD Committee Expert Working Group.  Optimizing pulmonary rehabilitation in chronic obstructive pulmonary disease – practical issues: A Canadian Thoracic Society Clinical Practice Guideline. Can Respir J 2010; 17(4): 159-168. [PDF]

  84. Boulet L-P, Devlin H, O’Donnell DE. The Physicians’ Practice Assessment Questionnaire on asthma and COPD. Respir Med 2010; 105(1): 8-14. [PDF]

  85. Guenette JA, Jensen D, O’Donnell DE.  Respiratory function and the obesity paradox.  Curr Opin Clin Nutr Metab Care 2010; 13(6): 618-624. [PDF]

  86. Deesomchok A, Webb KA, Forkert L, Lam Y-M, Ofir D, Jensen D, O’Donnell DE. Lung hyperinflation and its reversibility in patients with airway obstruction of varying severity. COPD 2010; 7(6): 428-437. [PDF]

  87. 2009 & Earlier

  88. Guenette JA, O’Donnell DE. Pulmonary edema in athletes: methodology or meaningful physiology? (comment on point:counterpoint) J Appl Physiol 2010; 109(4): 1277-1278. [PDF]

  89. Green HJ, Bombardier E, Burnett ME, D’Arigny CL, Iqbal S, Webb KA, Ouyang J, O’Donnell DE. Cellular assessment of muscle in COPD: case studies of two males. Int J Gen Med 2009; 2: 227-242. [PDF]

  90. O’Donnell DE. Cardiopulmonary exercise testing and pulmonary rehabilitation. In: Ware LB. Clinical year in review I: Interstitial lung disease, pulmonary vascular disease, pulmonary infections, and cardiopulmonary exercise testing and pulmonary rehabilitation. Proc Am Thorac Soc 2009; 6: 487-493. [PDF]

  91. Camp PG, O’Donnell DE, Postma DS. Chronic obstructive pulmonary disease in men and women: myths and reality. Proc Am Thorac Soc 2009; 6: 535-538. [PDF]

  92. Laveneziana P, Palange P, Ora J, Martolini D, O’Donnell DE. Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD. Eur J Appl Physiol 2009; 107(6): 633-643. [PDF]

  93. Ora J, Laveneziana P, Ofir D, Deesomchok A, Webb KA, O’Donnell DE. Combined effects of obesity and COPD on dyspnea and exercise tolerance. Am J Respir Crit Care Med 2009; 180: 964-971. [PDF]

  94. Green HJ, Burnett ME, D’Arsigny C, Iqbal S, Ouyang J, Webb KA, O’Donnell DE. Muscle fiber type characteristics in females with chronic obstructive pulmonary disease. A preliminary study. J Mol Histol 2009; 40(1): 41-51. [PDF]

  95. Green HJ, Burnett ME, D’Arsigny CL, Webb KA, McBride I, Ouyang J, O’Donnell DE. Vastus lateralis Na+-K+-ATPase activity, protein, and isoform distribution in chronic obstructive pulmonary disease. Muscle Nerve 2009; 40: 62-68. [PDF]

  96. Laviolette L, O’Donnell DE, Webb KA, Hamilton AL, Kesten S, Maltais F. Performance during constant workrate cycling exercise in women with COPD and hyperinflation. COPD: J of COPD 2009; 6(5):340-351. [PDF]

  97. Laveneziana P, O’Donnell DE, Ofir D, Agostoni P, Padeletti L, Ricciardi G, Palange P, Duranti R, Scano G. Effect of biventricular pacing on ventilatory and perceptual responses to exercise in patients with stable chronic heart failure. J Appl Physiol 2009; 106: 1574-1583. [PDF]

  98. Jensen, D, Ofir D, O’Donnell DE. Effects of pregnancy, obesity and aging on the intensity of perceived breathlessness during exercise in healthy humans. Respir Physiol Neurobiol 2009; 167(1): 87-100. [PDF]

  99. O’Donnell DE, Ora J, Webb KA, Laveneziana P, Jensen D. Mechanisms of activity-related dyspnea in pulmonary diseases. Respir Physiol Neurobiol 2009; 167(1): 116-132. [PDF]

  100. Jensen D, Webb KA, Davies GAL, O’Donnell DE. Mechanisms of activity-related breathlessness in healthy human pregnancy. Eur J Appl Physiol 2009; 106: 253-265. [PDF]

  101. O’Donnell DE, Travers J, Webb KA, He Z, Lam Y-M, Hamilton A, Kesten S, Maltais F, Magnussen H. Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD. Eur Respir J 2009; 34: 866-874. [PDF]

  102. O’Donnell DE. Bronchodilator therapy in COPD: physiological effects. Breathe 2008; 4(4): 342-344. [PDF]

  103. O’Donnell DE. Dynamic lung hyperinflation and its clinical implication in COPD. Rev Mal Respir 2008; 25(10):1305-18.

  104. O’Donnell DE, Webb KA. Last Word on Point-Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation. J Appl Physiol 2008; 105: 765. [PDF]

  105. O’Donnell DE, Webb KA. Point-Counterpoint: The major limitation to exercise performance in COPD is dynamic hyperinflation. J Appl Physiol 2008; 105: 753-755, discussion 755-757. [PDF]

  106. O’Donnell DE, Laveneziana P, Ora J, Webb KA, Lam YM, Ofir D. Evaluation of acute bronchodilator reversibility in symptomatic GOLD stage I COPD. Thorax 2009; 64: 216-223. [PDF]

  107. Green H, Burnett M, Duhamel T, D’Arsigny C, O’Donnell DE, Webb KA, Ouyang J. Abnormal sarcoplasmic reticulum Ca2+-sequestering properties in skeletal muscle in chronic obstructive pulmonary disease. Am J Physiol: Cell Physiol 295:C350-C357, 2008. [PDF]

  108. Green HJ, Bombardier EB, Burnett M, Iqbal S, D’Arsigny CL, O’Donnell DE, Ouyang J, Webb KA. Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive lung disease. Am J Physiol: Regul Integ Comp Physiol 295:R935-R941, 2008. [PDF]

  109. Green HJ, Burnett ME, D’Arsigny CL, O’Donnell DE, Ouyang J, Webb KA. Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive lung disease. J Appl Physiol 105:870-886, 2008. [PDF]

  110. O’Donnell DE, Hernandez P, Kaplan A, Aaron S, Bourbeau J, Marciniuk D, Balter M, Ford G, Gervais A, Lacasse Y, Maltais F, Road J, Rocher G, Sin D, Sinuff T, Voduc N. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease – 2008 update – highlights for primary care. Can Respir J 15(A):1A-8A, 2008. (Including letter to the editor; 15(4):219). [PDF]

  111. Aliverti A, Macklem PT, Debigare R, Maltais F, O’Donnell DE, Webb KA. Point: Counterpoint – The major limitations to exercise performance in COPD. J Appl Physiol 105:749-757, 2008. [PDF]

  112. Franssen FME, O’Donnell DE, Goossens GH, Blaak EE, Schols AMWJ. Obesity and the lung: 5. Obesity and COPD. Thorax 63:1110-1117, 2008. [PDF]

  113. Kaplan A, Hernandez P, O’Donnell, DE. Less smoke, more fire: What’s new for you in the latest COPD guidelines? Can Family Physician 54:737-739, 2008. [PDF]

  114. Jensen D, Webb KA, Davies GAL, O’Donnell DE. Mechanical ventilatory constraints during incremental cycle exercise in human pregnancy: implications for respiratory sensation. J Physiol 586:4735-4750, 2008. [PDF]

  115. Travers J, Dudgeon DJ, Amjadi K, McBride I, Dillon K, Laveneziana P, Ofir D, Webb KA, O’Donnell DE. Mechanisms of exertional dyspnea in patients with cancer. J Appl Physiol 104:57-66, 2008. [PDF]

  116. Aaron SD, Fergusson D, Marks GB, Suissa S, Vandemheen KL, Doucette S, Maltais F, Bourbeau JF, Goldstein RS, Balter M, O’Donnell D, FitzGerald M for the Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium. Counting, analysing and reporting exacerbations of COPD in randomised controlled trials. Thorax 63(2):122-128, 2008. [PDF]

  117. Ofir D, Laveneziana P, Webb K, Lam Y-M, O’Donnell D. Sex differences in the perceived intensity of breathlessness during exercise with advancing age. J Appl Physiol 104:1583-1593, 2008. [PDF]

  118. Ofir D, Laveneziana P, Webb KA, Lam YM, O’Donnell DE. Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I COPD. Am J Respir Crit Care Med
    177(6):622-629, 2008. [PDF] Online Data Supplement [PDF]Accompanying editorial by P. Calverley. [PDF]

  119. Jensen D, Duffin J, Lam M, Webb KA, Simpson JA, Davies GA, Wolfe LA, O’Donnell DE. Physiological mechanisms of hyperventilation during human pregnancy. Respir Physiol Neurobiology 161:76-86, 2008. [PDF]

  120. Jensen D, Amjadi K, Harris-McAllister V, Webb KA, O’Donnell DE. Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD. Thorax 63:606-613, 2008. [PDF]

  121. Laveneziana P, Jensen D, Webb KA, O’Donnell DE. Pharmacological treatment in chronic obstructive pulmonary disease. Current Respir Med Reviews 4(4):301-311, 2008.

  122. Laveneziana P, Wadell K, Webb KA, O’Donnell DE. Exercise limitation in chronic obstructive pulmonary disease. Current Respir Med Reviews 4(4):258-269, 2008.

  123. O’Donnell DE, Banzett RB, Carrierii-Kohlman V, Casaburi R, Davenport PW, Gandevia S, Gelb AF, Mahler DA, Webb KA. Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc Am Thoracic Soc 4(2):145-168, 2007. [PDF]

  124. Travers J, Laveneziana P, Webb KA, Kesten S, O’Donnell DE. Effect of tiotropium bromide on the cardiovascular response to exercise in COPD. Respir Med 101(9):2017-2024, 2007. [PDF]

  125. Jensen D, Webb KA, O’Donnell DE. Chemical and mechanical adaptations of the respiratory system at rest and during exercise in human pregnancy. Appl Physiol Nutr Metab 32(6):1239-1250, 2007. [PDF]

  126. Laveneziana P, Parker CM, O’Donnell DE. Ventilatory constraints and dyspnea during exercise in chronic obstructive pulmonary disease. Appl Physiol Nutr Metab 32(6):1225-1238, 2007. [PDF]

  127. Laveneziana P, O’Donnell DE. The role of spirometry in evaluating therapeutic responses in advanced COPD. Dis Manage Health Outcomes 15(2):91-100, 2007. [PDF]

  128. Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, Balter M, O’Donnell DE, et al. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 146(8):545-555, 2007. [PDF]

  129. Ofir D, Laveneziana P, Webb KA, O’Donnell DE. Ventilatory and perceptual responses to cycle exercise in obese females. J Appl Physiol 102(6):2217-2226, 2007. [PDF]Accompanying editorial by R.B Banzett and S.H. Loring. [PDF]

  130. Jensen D, Webb KA, Wolfe LA, O’Donnell DE. Effects of human pregnancy and advancing gestation on respiratory discomfort during exercise. Respir Physiolo Neurobiol 156(1):85-93, 2007. [PDF]

  131. Palange P, Ward SA, Carlsen KH, Casaburi R, Gallagher CG, Gosselink R, O’Donnell DE, Puente-Maestu L, Schols AM, Singh S, Whipp BJ. Recommendations on the use of exercise testing in clinical practice. European Respiratory Society Task Force Report. Eur Respir J 29(1):185-209, 2007. [PDF]

  132. O’Donnell DE, Laveneziana P. Dyspnea and activity limitation in COPD: mechanical factors. COPD 4(3):225-236, 2007. [PDF]

  133. O’Donnell DE, Aaron S, Bourbeau J, Hemandez P, Marciniuk D, et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can Respir J 14(Suppl B):5B-32B, 2007. [PDF]

  134. O’Donnell DE. Is sustained pharmacological lung volume reduction now possible in COPD? (Invited Editorial) Chest 129(3):501-503, 2006. [PDF]

  135. O’Donnell DE. Introduction, In: Hyperinflation: A critical target in COPD. (Guest Editor) Proc Am Thoracic Soc 3(2):175, 2006.

  136. O’Donnell DE. Hyperinflation, dyspnea and exercise intolerance in chronic obstructive pulmonary disease. Proc Am Thoracic Soc 3(2):180-184, 2006. [PDF]

  137. Nici L, Donner C, Wouters E, Zuwallack R, Abrosino N, Bourbeau J, Carone M, Celli B, O’Donnell D, et al. American Thoracic Society/European Respiratory Society Statement on Pulmonary Rehabilitation. Am J Respir Crit Care Med. 173(12):1390-1413, 2006. [PDF]

  138. O’Donnell DE, Parker CM. COPD exacerbations. 3: pathophysiology. Thorax 61(4):354-361, 2006. [PDF]

  139. Peters MM, Webb KA, O’Donnell DE. Combined physiological effects of bronchodilators and hyperoxia on dyspnoea normoxic COPD. Thorax 61(7):559-567, 2006. [PDF]Accompanying editorial by R. Casaburi. [PDF]

  140. O’Donnell DE, Sciurba F, Celli B, Mahler DA, Webb KA, Kalberg CJ, Emmett A, Knobil K. Effect of fluticasone propionate-salmeterol on lung hyperinflation and exercise endurance in COPD. Chest 130(3):647-656, 2006. [PDF]

  141. Lougheed MD, Fisher T, O’Donnell DE. Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception. Chest 130(4):1072-1081, 2006. [PDF]

  142. Tschakovsky ME, Saunders NR, Webb KA, O’Donnell DE. Muscle blood-flow dynamics at exercise onset: do the limbs differ? Med Sci Sports Exer 38(10):1811-1818, 2006. [PDF]

  143. O’Donnell DE, Hamilton AL, Webb KA. Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J Appl Physiol 101(4):1025-1035, 2006. [PDF] Accompanying editorial by K. Killian. [PDF]

  144. O’Donnell DE. Impacting patient-centred outcomes in COPD: breathlessness and exercise tolerance. Eur Resp Rev 15(99):37-41, 2006. [PDF]

  145. O’Donnell DE, Laveneziana P. The clinical importance of dynamic lung hyperinflation in COPD. COPD 3(4):219-232, 2006. [PDF]

  146. O’Donnell DE, Laveneziana P. Physiology and consequences of lung hyperinflation in COPD. Eur Respir Rev 15(100):61-67, 2006. [PDF]

  147. O’Donnell DE, Laveneziana P. Lung hyperinflation in COPD: the impact of pharacotherapy. Eur Respir Rev 15(100):85-89, 2006. [PDF]

  148. Jensen D, Wolfe LA, O’Donnell DE, Davies GA. Chemoreflex control of breathing during wakefulness in healthy men and women. J Appl Physiol 98(3):822-828, 2005. [PDF]

  149. Jensen D, Wolfe LA, Slatkovska L, Webb KA, Davies GA, O’Donnell DE. Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide. Am J Physiol Regul Integr Comp Physiol 288(5):R1369-R1375, 2005. [PDF]

  150. Rabe KF, Bateman ED, O’Donnell D, Witte S, Bredenbroker D, Bethke TD. Roflumilast – an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomized controlled trial. Lancet 366(9485):563-571, 2005. [PDF]

  151. Parker CM, Voduc N, Aaron SD, Webb KA, O’Donnell DE. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur Respir J 26(3):420-428, 2005. [PDF] Accompanying editorial by R. Rodriguez-Roisin. [PDF]

  152. Maltais F, Hamilton A, Marciniuk D, Hernandez P, Sciurba FC, Richter K, Kesten S, O’Donnell D. Improvements in symptom-limited exercise performance over 8 h with once-daily Tiotropium in patients with COPD. Chest 128(3):1168-1178, 2005. [PDF]

  153. Saberi F, O’Donnell DE. The role of tiotropium bromide, a long-acting anticholinergic bronchodilator, in the management of COPD. Treat Respir Med 4(4):275-281, 2005.

  154. Raghavan R, Ellis AK, Wobeser W, Sutherland KB, O’Donnell DE. Hemopneumothorax in a COPD patient treated with noninvasive positive pressure ventilation: the risk of attendant anticoagulation. Can Respir J 11(2):159-162, 2004.

  155. Voduc N, Webb KA, D’Arsigny C, McBride I, O’Donnell DE. McArdle’s disease presenting as unexplained dyspnea in a young woman. Can Respir J 11(2):163-167, 2004. [PDF]

  156. O’Donnell DE. What is unique about the new Canadian COPD Guidelines? Can Respir J 11(3);200-203, 2004.

  157. O’Donnell D, Flüge T, Gerken F, Hamilton A, Webb K, Aguilaniu B, Make B, Magnussen H. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 23(6):832-840, 2004. [PDF]

  158. O’Donnell DE, Voduc N, Fitzpatrick M, Webb KA. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J 24(1):86-94, 2004. [PDF]

  159. O’Donnell DE, Aaron S, Bourbeau J, et al. State of the Art Compendium: Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease. Can Respir J 11(Suppl B):7B-59B, 2004. [PDF]

  160. Aaron SD, Vandemheen K, Fergusson D, FitzGerald M, Maltais F, Bourbeau J, Goldstein R, McIvor A, Balter M, O’Donnell D. The Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment. Can Respir J 11(8):581-585, 2004.

  161. O’Donnell DE. Lung mechanics in COPD: the role of tiotropium. Eur Respir Rev 13(89):40-44, 2004.

  162. O’Donnell DE. COPD advances in exercise physiology. Exp Lung Res, 2004.

  163. Voduc N, O’Donnell DE. Tiotropium in the treatment of chronic obstructive pulmonary disease: Review of clinical trials. J New Developments in Clin Med 21(1):37-48, 2003.

  164. Voduc N, O’Donnell DE. Should your patients have cardiopulmonary exercise testing? J Respir Dis 24(3):106-117, 2003.

  165. O’Donnell DE, Hernandez P, Aaron S, Bourbeau J, et al. Canadian Thoracic Society COPD Guidelines: summary of highlights for family doctors. Can Respir J 10(4):183-185, 2003. [PDF]

  166. O’Donnell DE, Aaron S, Bourbeau J, et al. Canadian Thoracic Society Recommendations for management of chronic obstructive pulmonary disease. Can Respir J 10(Suppl A):11A-33A, 2003.

  167. Fitzpatrick M, McLean H, Urton AM, Tan T, O’Donnell DE, Driver HS. Effect of nasal or oral breathing route on upper airway resistance during sleep. Eur Respir J 22(5):827-832, 2003. [PDF]

  168. Newton M, O’Donnell DE, Forkert L. Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation. Chest 121(4):1042-1050, 2002. [PDF]

  169. Simpson JA, Labugger R, Hesketh G, D’Arsigny C, O’Donnell D, Matsumoto N, Collier CP, Iscoe S, Van Eyk JE. Differential detection of skeletal troponin I isoforms in serum of a patient with rhabdomyolysis: markers of muscle injury? Clin Chem 48(7):1112-1114, 2002. [PDF]

  170. Lougheed MD, Flannery J, Webb KA, O’Donnell DE. Respiratory sensation and ventilatory mechanics during induced bronchoconstriction in spontaneously breathing low cervical quadriplegia. Am J Respir Crit Care Med 166(3):370-376, 2002. [PDF]

  171. O’Donnell DE, D’Arsigny C, Fitzpatrick M, Webb KA. Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation. Am J Respir Crit Care Med 166(5):663-668, 2002. [PDF] – Accompanying editorial by J.A. Dempsey. [PDF]

  172. O’Donnell DE. Exercise and dyspnea. Eur Respir Rev 12(82):36-39, 2002. [PDF]

  173. O’Donnell DE. Exercise tolerance as a clinical outcome measure in COPD. Eur Respir Rev 12(86/87):303-304, 2002.

  174. O’Donnell DE. Clinical utility of work of breathing measurements in COPD. Eur Respir Rev 12(86/87):383-385, 2002. [PDF]

  175. O’Donnell DE, D’Arsigny C, Webb KA. Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163(4):892-898, 2001. [PDF]

  176. O’Donnell DE. Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc 35(7 Suppl):S647-655, 2001. [PDF]

  177. O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164(5):770-777, 2001. [PDF]

  178. O’Donnell DE, Forkert L, Webb KA. Evaluation of bronchodilator responses in patients with “irreversible” emphysema. (Letter to the Editor) Eur Respir J 18(6):914-920, 2001. [PDF]

  179. O’Donnell DE. Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful? (Review) Chest 117(2 Suppl):42S-47S, 2000. [PDF]

  180. O’Donnell DE, Hong HH, Webb KA. Respiratory sensation during chest wall restriction and dead space loading in exercising men. J Appl Physiol 88(5):1859-1869, 2000. [PDF]

  181. Banzett RB, Dempsey JA, O’Donnell DE, Wambolt MZ. Symptom perception and respiratory sensation in asthma. Am J Respir Crit Care Med 162(3 Pt 1):1178-1182, 2000. [PDF]

  182. Bain DJ, Webb KA, O’Donnell DE. Pulmonary arteriovenous malformation as a cause of severe exertional dyspnoea. Int J Clin Pract 53(2):142-144, 1999.

  183. Newton M, Webb KA, O’Donnell DE. Testing for exercise limitation in obstructive lung disease. Chest 115(6):1755-1757, 1999. [PDF]

  184. Meek P, Schwartzstein RM, Adams L, Altose MD, Breslin EH, Carrieri-Kohlman V, Gift A, Hanley MV, Harver A, Jones PW, Killian K, Knebel A, Lareau SC, Mahler DA, O’Donnell DE, Steele B, Stuhlbarg M, Titler M. Dyspnea. Mechanisms, assessment and management: a consensus statement. American Thoracic Society. (Review) Am J Respir Crit Care Med 159(1):321-340, 1999. [PDF]

  185. O’Donnell DE, Lam M, Webb KA. Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160(2):542-549, 1999. [PDF]

  186. O’Donnell DE, D’Arsigny C, Raj S, Abdollah H, Webb KA. Ventilatory assistance improves exercise endurance in stable congestive heart failure. Am J Respir Crit Care Med 160(6):1804-1811, 1999. [PDF]

  187. Giustino J, Webb KA, Sutherland KB, O’Donnell DE. Severe exertional dyspnea in a patient with localized emphysema. Can Respir J 6(6):535-539, 1999.

  188. Chau LK, Webb KA, Jackson AC, O’Donnell DE. Vocal cord paralysis and respiratory muscle weakness: an unusual presentation of chronic polyneuropathy. Can Respir J 5(2):125-129, 1998.

  189. Shinder N, Polson A, Pringle E, O’Donnell DE. Neuralgic Amyotrophy: A rare cause of bilateral diaphragmatic paralysis. Can Respir J 5(2):139-142, 1998.

  190. O’Donnell, DE. Dyspnea in Advanced chronic obstructive pulmonary disease. J Heart Lung Transplant 17(6):544-554, 1998.

  191. O’Donnell DE, McGuire M, Samis L, Webb KA. General exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitation. Am J Respir Crit Care Med 157(5 Pt 1):1489-1497, 1998. [PDF]

  192. O’Donnell DE, Lam M, Webb KA. Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158(5 Pt 1):1557-1565, 1998. [PDF]

  193. O’Donnell DE, Chau LK, Webb KA. Qualitative aspects of exertional dyspnea in patients with interstitial lung disease. J Appl Physiol 84:2000-2009, 1998. [PDF]

  194. D’Arsigny CL, Ford S, O’Donnell DE. Localized upper airway obstruction in a patient with acquired immunodeficiency syndrome. Postgrad Med J 74:604-606, 1998.

  195. O’Donnell, DE, Bertley JC, Chau LK, Webb KA. Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiological mechanisms. Am J Respir Crit Care Med, 155(1):109-115, 1997. [PDF]

  196. O’Donnell DE, Bain DJ, Webb KA. Factors contributing to relief of exertional breathlessness during hyperoxia in chronic airflow limitation. Am J Respir Crit Care Med 155(2):530-535, 1997.

  197. Kern DG, Durand KTH, Crausman RS, Never A, Kuhn III C, Lougheed MD, O’Donnell DE, Munt PW, Vanderslice RR. Chronic interstitial lung disease in nylon flocking industry workers--Rhode Island, 1992-1996. Morbidity and Mortality Weekly Report, Centres for Disease Control & Prevention, Atlanta, 46(38):897-900, 1997.

  198. D’Arsigny C, O’Donnell DE. Will exercise help my COPD patient? (Review) Med North America 20:40-46, 1997.

  199. O’Donnell, DE. Volume reduction surgery in patients with chronic airflow limitation: A physiological rationale. Seminars in Respir and Crit Care Med 17:509-516, 1996.

  200. O’Donnell DE. Towards the alleviation of chronic breathlessness. “Ontario Thoracic Reviews” 8:5-7, 1996.

  201. O’Donnell DE, Webb KA, Bertley JC, Conlan AA. Mechanisms of relief of exertional breathlessness following unilateral bullectomy and lung volume reduction surgery in emphysema. Chest 110(1):18-27, 1996. [PDF]

  202. Lemoine JR, O’Donnell DE. “Focus on Respiratory Health”, “Asthma and COPD”, Issue 1, 1-4, 1996.
  203. O’Donnell DE, McGuire M, Samis L, Webb KA. The impact of exercise reconditioning on breathlessness in severe chronic airflow limitation. Am J Respir Crit Care Med 152(6 Pt 1):2005-2013, 1995.

  204. Lougheed MD, Webb KA, O’Donnell DE. Breathlessness during induced hyperinflation in asthma: the role of the inspiratory threshold load. Am J Respir Crit Care Med 152(3):911-920, 1995.

  205. Chau LL, O’Donnell DE. Investigation of hemoptysis. Medicine North America 333-345, 1995.

  206. Chau LL, O’Donnell DE. Cough variant asthma. The Canadian Journal of Asthma Management 2(1):4-6, 1995.

  207. O’Donnell DE. Breathlessness in advanced COPD: therapeutic strategies. (Invited review) “Ontario Thoracic Reviews”, 6:1-7, 1994.

  208. O’Donnell DE. Breathlessness in patients with chronic obstructive pulmonary disease. Mechanisms and management. (Review) Chest 106(3):904-912, 1994. [PDF]

  209. Luce K, O’Donnell DE, Morton AR. A combination of calcitonin and bisphosphonate for the emergency treatment of severe tumour-induced hypercalcemia. (Case Report) Calcif Tissue Int 52(1):70-71, 1993.

  210. O’Donnell DE, Webb KA, McGuire MA. Older patients with COPD: benefits of exercise training. (Review) Geriatrics 48(1):59-66, 1993.

  211. O’Donnell DE, Sanii R, Loveridge B, Younes M. Steady-state ventilatory responses to expiratory resistive loading in quadriplegics. Am Rev Respir Dis 147(1):54-59, 1993.

  212. O’Donnell DE, Webb KA. Exertional breathlessness in patients with chronic airflow limitation: the role of lung hyperinflation. Am Rev Respir Dis 148(5):1351-1357, 1993.

  213. Lougheed MD, Webb KA, Forkert L, O’Donnell DE. Breathlessness during acute bronchoconstriction in asthma: pathophysiologic mechanisms. Am Rev Respir Dis 148(6 Pt 1):1452-1459, 1993. [PDF]

  214. O’Donnell DE, Webb K. Breathlessness in patients with severe chronic airflow limitation. Physiological correlations. Chest 102(3):824-831, 1992. [PDF]

  215. O’Donnell DE. “Quest for Cures, Respiratory Research at Queen’s University”. The Lung Association, The Lung Letter, Vol 6, No 2, Spring & Autumn 1992.

  216. Mahler DA, O’Donnell DE. Alternative modes of exercise training for pulmonary patients. J Cardiopulm Rehab 11:58-63, 1991.

  217. O’Donnell DE, Sanii R, Younes M. Improvement in exercise endurance in patients with chronic airflow limitation using continuous positive airway pressure. Am Rev Respir Dis 138(6):1510-1514, 1988.

  218. O’Donnell DE, Sanii R, Giesbrecht G, Younes M. Effect of continuous positive airway pressure on respiratory sensation in patients with chronic obstructive pulmonary disease during submaximal exercise. Am Rev Respir Dis 138(5):1185-1191, 1988.

  219. O’Donnell DE, Sanii R, Younes M. External mechanical loading in conscious humans: role of upper airway mechanoreceptors. J Appl Physiol 65(2):541-548, 1988. [PDF]

  220. Kelly CP, O’Donnell D, West B, Clancy L. Small cell and squamous cell lung carcinomas: sequential occurrence at a single site. Thorax 42(10):821-822, 1987.

  221. O’Donnell DE, Sanii R, Anthonisen NR, Younes M. Expiratory resistive loading in patients with severe chronic air-flow limitation. An evaluation of ventilatory mechanics and compensatory responses. Am Rev Respir Dis 136(1):102-107, 1987.

  222. O’Donnell DE, Sanii R, Anthonisen NR, Younes M. Effect of dynamic airway compression on breathing pattern and respiratory sensation in severe chronic obstructive pulmonary disease. Am Rev Respir Dis 135(4):912-918, 1987.

  223. O’Donnell D, Cotter P, Kennedy N, Clancy L. An open steady-state pharmacokinetic study to compare Pro-vent and Phyllocontin in asthmatic patients. Br J Clin Pract 40(8):318-322, 1986.

  224. Fitzgerald DJ, O’Donnell DE, O’Brien ET, O’Malley K. Assessment of non-invasive automatic ambulatory blood pressure recorder: DelMar Avionics pressureometer. J Hypertension 3(53):5;359-361, 1985.

  225. O’Donnell D, Kelly CP, Cotter P, Clancy L. Use of oxygen driven nebulizer delivery systems for beta-2 agonists in chronic bronchitis. Ir J Med Sci 154(5):198-200, 1985.

    BOOKS

  1. Dyspnea: Mechanisms, Measurement and Management. Eds. D. Mahler, D.E. O’Donnell. Marcel Dekker Inc., Lung Biology in Health & Disease 2005; 208.

  2. Exercise Physiology in COPD: The Impact of Tiotropium. Eur Respir Rev Monograph. Ed. D.E. O’Donnell, 2004 (In press).

    BOOK CHAPTERS

  1. Laveneziana P, Webb KA, O’Donnell DE. Static and dynamic hyperinflation in chronic obstructive pulmonary disease. In: Aliverti A, Pedotti A, eds. Mechanics of Breathing: New Insights from New Technologies. Springer Press. Chapter 7: 73-98, 2014.

  2. O’Donnell DE, Laveneziana P, Neder JA. Lung function. European Respiratory Monograph 2013; 62: 127-145. [M Kolb and CF Vogelmeier, eds. Outcomes in Clinical Trials]

  3. Parker CM, Fitzpatrick MF, O’Donnell DE. Physiology of interstitial lung disease. In: Interstitial Lung Disease, 5th edition. MI Schwarz, TE King, eds.  Hamilton, ON: BC Decker Inc.  2011: 61-79.

  4. Lougheed MD, Ora J, O’Donnell DE.  Long-acting muscarinic antagonists in asthma and COPD.  In: Advances in Combination Therapy for Asthma and COPD.  2009 (submitted).

  5. Laveneziana P, Ora J, Webb KA, O’Donnell DE.  Lung volumes in COPD.  In:  Cazzola M, Martinez FJ, Page CP, editors. COPD Outcomes and Biomarkers. In: Lenfant C, editor. Lung Biology in Health and Disease Series. New York: Informa Healthcare, publication date January 2010.

  6. Parker CM, Fitzpatrick MF, O’Donnell DE. Physiology of Interstitial Lung Disease. In: Schwarz MI, King TE, eds. Interstitial Lung Disease. Hamilton, ON: BC Decker; publication data March 29, 2010.

  7. O’Donnell DE, Fisher J, editors. Special Issue: The clinical physiology and integrative neurobiology of dyspnea. Respir Physiol Neurobiol 2009; 167(1): 1.

  8. O’Donnell DE, Ofir D, Laveneziana P. Patterns of cardiopulmonary response to exercise in lung diseases. European Respiratory Monograph. Eds. P. Palange & S. Ward. In: Clinical Exercise Test Interpretation. 40:69-92, Chpt. 3, 2007.

  9. Parker CM, O’Donnell DE. Dynamic hyperinflation, dyspnea and exercise intolerance in chronic obstructive pulmonary disease. In: Essentials of COPD. 5:3-30, 2005 [PDF].

  10. Peters M, O’Donnell DE. Dyspnea in chronic obstructive pulmonary disorder. In: Dyspnea in Advanced Disease, Ed. S. Booth , D. Dudgeon. Oxford University Press. 55-74: Chpt. 4, 2005.

  11. Voduc N, O’Donnell DE. Pulmonary rehabilitation. In: Dyspnea in Advanced Disease. Eds. S. Booth, D. Dudgeon. Oxford University Press 137-155: Chpt. 9, 2005.

  12. O’Donnell DE, Mahler DA. Effective bronchodilator and inhaled corticosteroids on dyspnea in COPD. In: Dyspnea: Mechanisms, Measurement and Management. Marcel Dekker Inc. Eds. D. Mahler, D.E. O’Donnell. Lung Biology in Health & Disease 208:283-300, Chpt. 12, 2005.

  13. O’Donnell DE, Webb. Mechanisms of dyspnea in chronic obstructive pulmonary disease. In: Dyspnea: Mechanisms, Measurement and Management. Marcel Dekker, Inc. Eds. D. Mahler, D.E. O’Donnell. Lung Biology in Health & Disease 208:29-58, Chpt. 3, 2005.

  14. O’Donnell De, Voduc N. Mechanisms of dyspnea in restrictive lung disorders. In: Dyspnea: Mechanisms, Measurement and Management. Marcel Dekker, Inc. Eds. D. Mahler, D.E. O’Donnell. Lung Biology in Health & Disease 208:87-114, Chpt. 5, 2005.

  15. Lougheed MD, O’Donnell DE. Dyspnea in asthma. In: Dyspnea: Mechanisms, Measurement and Management. Marcel Dekker Inc. Eds. D. Mahler, D.E. O’Donnell. Lung Biology in Health & Disease 208:59-86, Chpt 4, 2005.

  16. Voduc N, Webb KA, O’Donnell DE. Physiological basis of dyspnea. In: Pulmonary Rehabilitation. Eds. Donner CF, Ambrosino A, Goldstein R. Chp.13:124-135, 2005.

  17. O’Donnell DE, Webb KA. Exercise Testing. In: Pharmacotherapy in COPD. Ed. B. Celli. Marcel Dekker, 182:chp 3:45-71, 2004.

  18. O’Donnell DE, M. Fitzpatrick. Assessment of disability: What test or combination of tests should be used?” In: Chronic Obstructive Pulmonary Disease: Critical Debates. Eds. M. Pearson, W. Wedzicha. Blackwell Science. Chp 5: 63-83, 2003.

  19. O’Donnell DE, Voduc N. Management of advanced chronic obstructive pulmonary disease. In: Non-Neoplastic Advanced Lung Disease. Ed. J.R. Maurer. Marcel Dekker Inc. 176:117-179, 2003.

  20. Voduc N, O’Donnell DE. Drug therapy in chronic obstructive pulmonary disease. In: Drug Advances. Ed. J. Gray. 1:31-44, 2003.

  21. O’Donnell DE, Webb KA. Exercise. In: Chronic Obstructive Pulmonary Disease, 2E. Eds. Calverley, MacNee, Rennard & Pride. Edward Arnold (Publishers) Ltd. Chp. 18:243-269, 2003.

  22. O’Donnell DE, Fitzpatrick M. Physiology of interstitial lung disease. In: Interstitial Lung Disease. 4th Edition. Ed. Swartz & King. B.C. Decker, pp 54-75, 2003.

  23. O’Donnell DE. Exercise limitation and clinical exercise testing in chronic obstructive lung disease. In: Clinical Exercise Testing: Progress in Respiratory Research. Eds. J. Zebellos, I. Weisman. Karger Series, 32:138-158, 2002.

  24. O’Donnell DE, Webb KA, Revill SM. Mechanical ventilation during exercise in COPD. In: Advancing the Frontiers of Cardiopulmonary Rehabilitation. Eds. J. Jobin, F. Maltais, P. Poirier, P. LeBlanc, C. Simard. Chp. 11, pp 91-105, Champaign, Human Kinetics. 2002.

  25. O’Donnell DE, Webb KA, McGuire M. Controlling breathlessness and cough in COPD. In: Comprehensive Reference Guide for the Health Professional Taking Care of Patients with COPD. Eds. J. Bourbeau, D. Nault, E. Borycki. Chp 9; pp 149-170, 2002.

  26. O’Donnell DE. The assessment and management of dyspnea in the clinical management of COPD. In: “Management of COPD”. Lung Biology in Health and Disease Series. Eds. Similowski T, Whitelaw WA, Derenne J-P. Chap 7:113-170, 2002.

  27. O’Donnell DE. The etiology of dyspnea during exercise in COPD. In: Pulmonary Critical Care pdate. CD-Rom. www.uptodate.com. 2000.

  28. O’Donnell DE. “Physiology of Interstitial Lung Disease”. IN: Interstitial Lung Disease, 3rd
    Edition, Ed’s. Swartz and King. 3rd Edition (Published by B.C. Decker). 51-71, 1998.

  29. O’Donnell DE, Webb KA. Measurement of respiratory volume and flow. IN: Principles and Practice of Intensive Care Monitoring, Ed. M. Tobin. chap. 4, p. 63-80, 1998.

  30. O’Donnell DE. Exertional breathlessness in chronic respiratory diseases. Lung Biology in Health and Disease Series, “Dyspnea”, Marcel Dekker, Ed. D. Mahler. 11:97-147, 1998.

  31. O’Donnell DE, Webb KA. Exercise reconditioning in chronic airflow limitation. Eds. Torg, Shepherd, IN: Current Therapy in Sports Medicine, 3rd Edition, pg 678-684, 1995.

  32. O’Donnell DE, Webb KA. Breathlessness in patients with severe chronic airflow limitation: Physiological Correlations. In: RC Bone, TL Petty (eds) Year Book of Pulmonary Disease 1994. Mosby-Year Book, Inc., St. Louis p 136-139, 1994.