School of Graduate Studies

School of Graduate Studies
School of Graduate Studies

Biochemistry

EFFECTIVE 2014-2015, THE COURSES LISTED BELOW OR THE EQUIVALENT ARE  UNDER THE DEPARTMENT OF BIOMEDICAL AND MOLECULAR SCIENCES. CURRENT COURSE NUMBERS AND DESCRIPTIONS CAN BE FOUND HERE: COURSES OF INSTRUCTION BIOMEDICAL AND MOLECULAR SCIENCES.

STUDENTS ENROLLED IN BIOCHEMISTRY PROGRAMS IN 2013-2014 OR EARLIER ENROL IN COURSES WITH THE COURSE CODES AND NUMBERS AS SHOWN BELOW.

BCHM-810*     Protein Structure and Function     3L/T
This course presents an integrated approach to the study of protein function.  Topics include proteomic techniques in protein profiling, mass spectrometry, 2-D gel electrophoresis, yeast 2-hybrid analysis, protein chips, protein purification, imaging, surface plasmon resonance, calorimetry, bioinformatics and protein evolution, protein modifications and processing, interpretation and applications of 3-D structure, protein structure-function relationships. Three lecture hours per week; Fall. A. Mak.  Offered jointly with BCHM-410* with additional work required. PRE-REQUISITES:  BCHM-310 or 315*/316*/317* or permission of the instructor.
EXCLUSION: BCHM-410*

BCHM-811*     Advanced Molecular Biology     3L/T
This course concentrates on the molecular biology of mammalian models particularly mechanisms involved in human diseases. The human genome project, forensic analysis, DNA diagnostics of human diseases, models of transcriptional and growth regulation and cancer, DNA repair, RNA processing and translation are all discussed. Emphasis on recent findings and course materials will be drawn from current reviews.
Three lecture hours per week.  Winter. C. Mueller.  Offered jointly with BCHM-411* with additional work required.
PREREQUISITE: BCHM-310 or 315*/316*/317* or permission of the instructor
EXCLUSION: BCHM-411*.

BCHM-820*     Advanced Topics in Molecular Biology     
Discussions and presentations on current topics in molecular biology.  The emphasis will be on mammalian systems and will cover a wide range of topics relating to recent advances in molecular biology.  Typical topics include gene regulation, replication, DNA repair, forensic analysis, human genomics and genetics.  Marks are based on student presentations and essays typically in "News and Views" or Mini-Review formats.  Three hours per week, presentations and discussions of original papers.  Fall;  Alternate years;  C. Mueller.

BCHM-822*     Mechanisms of Metabolic Control     
Lectures and discussions on mechanisms of metabolic control. Recent research on a wide range of specific metabolic systems is examined critically. Emphasis is placed on biochemical factors and principles which play a role in the integration and control of metabolism.
Lectures and seminars, three hours per week; Winter; G.P.Côté.
PREREQUISITE: BCHM-431* or equivalent.

BCHM-823*     Advances in Protein Structure and Function     
This course consists of weekly presentations and discussions of recent advances towards the understanding of protein structure and function. Topics of discussion include novel approaches, techniques and concepts in the discovery of protein functions. Students will develop skills in literature research, critical evaluation of published work, effective presentation and discussion of papers.A specific theme, such as cell motility, may be used to illustrate research approaches employed to study biological systems in general. Three lecture hours per week; Winter; Alternate years; A. Mak. PREREQUISITE: BCHM-410* or equivalent.

BCHM-828*/928*     Research Project in Biochemistry     
This course is intended to provide the student with the opportunity to gain familiarity with their research field. Students will review the literature related to their proposed graduate research thesis project and write a series of essays on topics selected in consultation with their supervisor; these will be evaluated by a supervisory committee consisting of their supervisor and two other faculty members. They will also develop a written draft research proposal that will be presented to their supervisory committee and defended in a final oral examination. This course is not mandatory but is highly recommended to be taken by students in the first full term of the graduate program. G.P. Côté (course coordinator).

BCHM-830     Biochemistry Seminar Program for M.Sc. students     

BCHM-832*     Molecular Basis of Cell Function     
This course provides an introduction to the signaling pathways that regulate key cellular functions such as growth and motility.  The biochemical and structural principles that underlie the regulation of enzyme and protein activity in cells are emphasized.  Topics include protein kinases and phosphatases, ubiquitin modification, G-protein-coupled receptors, growth factor receptors, scaffold and adaptor proteins, Ras GTPases, phospholipases, oncogenes, cyclic nucleotides, phosphoinositides, isoprenoids and steroid hormones.  Offered jointly with BCHM 432. Three lecture hours per week. Fall; G.P. Côté.  PREREQUISITE: BCHM 310, or BCHM 315 and BCHM 316 and BCHM 317 for BCHM students; BCHM 310, or BCHM 315 and BCHM 316 for LISC students (or equivalent).  
EXCLUSION: BCHM432 (BCHM 431,BCHM 433, BCHM 831* and BCHM 833*).  

BCHM-841*     Current Topics in Biochemistry I     
This course will focus on protein structure and function with special emphasis on membrane proteins and selected soluble protein systems. The course will consist of lectures and presentations that will be organized around specific readings from the recent literature. A portion of the course will be devoted to membrane protein structure and function. Selected examples of structural and functional studies of soluble proteins will include enzymes and inhibitors; protein-protein interactions; protein engineering; high-throughput identification of enzyme substrates. Some instruction will be given in homology modeling and database analysis of gene products. Three hours per week, half course lectures and seminars. Fall; Alternate years; B. Hill, P. Davies. Prerequisite: BCHM 410* and BCHM 411* (or equivalent) and permission of co-ordinator.     

BCHM-899     Master's Thesis Research     

BCHM-930     Biochemistry Seminar Program for Ph.D. students     

BCHM-999     Ph.D. Thesis Research