Our research work is focused on the characterization and management of obesity and related co-morbidities in adults. In recent years we have conducted a number of randomized controlled trials to determine the efficacy and effectiveness of lifestyle-based interventions designed to manage abdominal obesity and related health risk. Our objective is to continue this type of research for the foreseeable future.
Our intervention-based research is performed within 5000 square feet of space in the School of Kinesiology and Health Studies. This space includes the aerobic exercise equipment necessary to perform multiple intervention trials. Equipment for measurement of indirect calorimetry both during exercise and at rest is in place. Also included are 4 MRI- and CT-image analysis workstations. We also have routine access to MRI, MRS, CT and DEXA facilities at Kingston General Hospital. Our cardiometabolic-based research is performed within our Clinical laboratory space located within our laboratory and includes 2 beds, office space for our research nurses and two metabolic testing suites dedicated to performing our metabolic studies including hyperinsulinemic euglycemic clamp studies, glucose tolerance, glucose oxidation, resting metabolic rate measurement etc.
As the prevalence of obesity, diabetes and aging continue to increase worldwide, the importance of research designed to develop graduate students trained in these research areas is magnified. The research objectives of our laboratory are consistent with this observation and thus, graduate students in our lab are trained in fertile research areas that will develop the skills required within a broad spectrum of the research community. To date 31 M.Sc and 6 PhD students have graduated from our laboratory.
Canadian Institute of Health Research (CIHR)
Recent, Selected Publications (2012-2014)
Ross R, Hudson R, Stotz P, Lam M. Effects of exercise amount and intensity on abdominal obesity and glucose tolerance in obese adults. A randomized controlled trial. Annals of Internal Medicine March 3, 2015.
Nazare JA, Smith JD, Borel A-L, Haffner SM, Balkau B, Ross R, Massien C, Alméras N, Després J-P. Usefulness of Measuring Both Body Mass Index and Waist Circumference for the Estimation of Visceral Adiposity and Related Cardiometabolic Risk Profile Am J Cardiol 115:307-315, 2015.
Ross R, Blair SN, de Lannoy L, Després J-P, Lavie CJ. Changing the endpoints for determining effective obesity management. Progress in Cardiovascular Diseases doi: 10.1016/j.pcad.2014.10.003, 2014.
Sallis R, Franklin B, Joy L, Ross R, Sabgir D, and Stone J. Strategies for Promoting Physical Activity in Clinical Practice. Progress in Cardiovascular Diseases doi: 10.1016/j.pcad.2014.10.003, 2014.
Ainsworth B, Cahalin L, Ekelund U, Ross R. The Current State of Physical Activity Assessment Tools Progress in Cardiovascular Diseases doi: 10.1016/j.pcad.2014.10.005, 2014.
Borel AL, Nazare JA, Smith J, Aschner P, Barter P, Van Gaal L, Tan CE, Wittchen H-U, Matsuzawa J, Kadowaki T, Ross R, Brulle-Wohlhueter C, Alméras N, Haffner SM, Balkau B, Després JP. Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance. International Journal of Obesity doi: 10.1038/ijo.2014.163, 2014.
Brennan A, Lam M, Paula S, Hudson R and Ross R. Exercise-induced change in insulin resistance is mediated by abdominal obesity but not cardiorespiratory fitness. Diabetes Care 37:e95–e97, 2014.
Wilson M, and Ross R. Measurement of muscle insulin sensitivity in obese men. Diabetes and Metabolism, 40 161–164, 2014.
Shalev-Goldman E, McGuire KA, and Ross R. Waist circumference and cardiorespiratory fitness are independently associated with glucose tolerance and insulin resistance in obese women. Appl Physiol Nutr Metab 39(3): 358-362, 2014.
Garland SJ, Holden RM, Ross R, Adams MA, Nolan RL, Hopman WH and Morton AR. Insulin resistance is associated with Fibroblast Growth Factor-23 in stage 3-5 chronic kidney disease patients. Journal of Diabetes and its Complications 28(1);61-5, 2014.
O’Neill TG, Guaraldi G, Orlando F, Carli E, Garlassi S, Zona S, Després J-P, and Ross R. Combined use of waist and hip circumference to identify high-risk, abdominally obese HIV-infected patients. PloS One 8(5): e62538, 2013.
Ross R, Hudson R, Day AG, and Lam M. Dose-response effects of exercise on abdominal obesity and risk factors for cardiovascular disease in adults: Study rationale, design and methods. Contemp Clin Trials. 34(1):155-60, 2013.
Smith JD, Nazare JA, Borel AL, Aschner P, Barter PJ, Van Gaal L,Tan C, Wittchen H-U, Matsuzawa Y, Kadowaki K, Ross R, Brulle-Wohlhuete C, Alméras N, Haffner SM, Balkau B, Després J-P. Assessment of cardiometabolic risk and prevalence of meeting treatment guidelines among patients with type 2 diabetes stratified according to their use of insulin and/or other diabetic medications: results from INSPIRE ME IAA. Diabetes Obes Metab. 15(7): 629-41, 2013.
Perry A, Wang X, Goldberg R, Ross R, Jackson L. Androgenic sex steroids contribute to metabolic risk beyond intra-abdominal fat in overweight/obese black and white women. Obesity 21: 1618-1624, 2013.
Tonorezos ES, Robien K, Eshelman-Kent D, Moskowitz CS, Church TS, Ross R and Oeffinger KC. Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia. Cancer Causes Control 24:313–321, 2013.
Malhotra J, Tonorezos ES, Rozenberg M, Vega GL, Sklar CA, Chou J, Moskowitz C, Eshelman-Kent DA, Janiszewski P, Ross R, and Oeffinger KC. Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia. J Lipid Res. 53(12):2747-54, 2012.
Nazare JA, Smith JD, Borel A-L, Haffner SM, Balkau B, Ross R, Massien C, Alméras N, Després J-P. Ethnic influences on the relationships between abdominal subcutaneous and visceral adiposity, liver fat and cardiometabolic risk profile: The INSPIRE ME IAA study. Am J Clin Nutr 96(4):714-26, 2012.
Saunders TJ, Palombella A, McGuire KA, Janiszewski PM, Després J-P, Ross R. Acute exercise increases adiponectin levels in abdominally obese men. J Nutr Metab. 2012:148729. doi: 10.1155/2012/148729. Epub May 30, 2012.
Janssen I, and Ross R. Vigorous intensity physical activity is related to the metabolic syndrome independent of the physical activity dose. International Journal of Epidemiology 41(4):1132-40, 2012.
Ross R, Lam, M, Blair SN, Church TS, Godwin M, Hotz SB, Johnson A, Katzmarzyk PT, Lévesque L, MacDonald S. Prevention and Reduction of Obesity through Active Living (PROACTIVE) in clinical settings: A randomized controlled trial. Archives of Internal Medicine 172(5):414-424, 2012.
Berentzen TL, Ängquist L, Kotronen A, Borra R, Yki-Järvinen H, Iozzo P, Parkkola R, Nuutila P, Ross R, Allison DB, Heymsfield SB, Overvad K, Sørensen TIA and Jakobsen M. Waist circumference adjusted for body mass index and intra-abdominal fat mass. PLoS One 7(2): e32213, 2012.
Smith JD, Borel A-L, Nazare J-A, Haffner SM, Balkau B, Ross R, Massien C, and Després J-P. Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: The INSPIRE ME IAA Study. J Clin Endocrinol Metab. 97(5):1517-25, 2012.