There are 3 types of amendments:
- Administrative amendments are straightforward changes to the protocol which do not affect animal use or welfare. They are reviewed and approved by the UACC Coordinator
- Minor amendments are changes to the protocol which may affect animal use or welfare, but do not increase the category of invasiveness. They are reviewed by the UACC Subcommittee.
- Major amendments are changes which affect animal use or welfare, including but not limited to those increasing the original category of invasiveness. The UACC meets once per month, therefore major amendments can only be processed on a monthly basis. Substantial modifications may result in a request to submit a completely new Animal Use Protocol.
Proposed changes that constitute a new protocol submission include:
- A change in main objective or in direction of research (hypotheses/objectives)
- Major changes to the approved experimental protocol (i.e.: addition of novel or invasive surgeries or procedures that significantly extend the scope of animal use and/or increase the level of invasiveness.)
- Addition of a level E category of invasiveness procedure. (This generally requires the submission of a pilot protocol).
- Click on MY DASHBOARD (top right hand corner -> PROTOCOLS for ANIMALS -> Amend and Renew Protocols -> Amend a Protocol
Choose protocol to be amended
Choose amendment form
- When subsequent amendments are being generated within the same approval period the previous amendment content will populate on the amendment page, this needs to be replaced with the new amendment content. Previous amendments are saved in Topaz history.
- All new changes being proposed need to be listed; explained and justified. These changes need to be implemented into the body of the protocol as well. i.e.: new personnel need to be added from the database drop down list, and changes to numbers or procedures need to be incorporated into the specific species sections.
- If new procedures are being added or changes to procedures proposed, please ensure that the species/strain/breed that will be involved is indicated as well as the number of animals that will be affected by the change. It is important that all changes flow cohesively within the original protocol and so should be incorporated into the timeline, thus showing how the new changes interact with the originally approved procedures.
- When additional numbers are being requested please ensure that both an explanation of the numbers as well as a justification is provided. Additional animals are often required for a number of reasons including a shift in focus, increase in laboratory personnel, a higher instance of complication, original underestimation etc.
- When numbers are being changed please ensure that the body of the protocol is updated accordingly and consistently. The SSB Use Details table, Authorized Amounts per Pain/Distress Category question and the Justification- Numbers Selected question all relate to numbers and therefore should refer to a consistent number of animals.