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BCHM 411  Advanced Molecular Biology  Units: 3.00  
This course concentrates on the molecular biology of mammalian models particularly mechanisms involved in human diseases. The human genome project, forensic analysis, DNA diagnostics of human diseases, models of transcriptional and growth regulation and cancer, DNA repair, RNA processing and translation are all discussed. Emphasis on recent findings and course materials will be drawn from current reviews. 
Learning Hours: 120 (36 Lecture, 84 Private Study)  
Requirements: Prerequisite ([Level 4 or above and registration in the BCHM Specialization or Major Plan] and [a minimum GPA of 2.50 in BCHM 218/3.0; BCHM 313/3.0; BCHM 315/3.0; BCHM 316/3.0; BCHM 317/6.0]) or ([Level 4 or above and registration in the LISC Specialization or Major Plan] and [a minimum GPA of 2.50 in BCHM 218/3.0 and [BCHM 310/9.0 or [BCHM 315/3.0 and BCHM 316/3.0]).  
Offering Faculty: Faculty of Health Sciences  

Course Learning Outcomes:

  1. Understand the physical and functional properties of the human genome
  2. Use Bioinformatic tools to identify human variation and assess their significance
  3. Understand how genome variation is assessed and contributes to human disease and therapies
  4. Interprete the significance of SNPs and cancer mutations
  5. Understand how microRNA’s control gene expression
  6. Understand the applications of genome editing tools to research and therapy
  7. Understand how epigenetics can control gene expression
  8. Know the role of stem cells in development and disease
  9. Anaylse and interprete contriversial scientific literature and present findings from advanced molecular biology-related research articles to your peers