Human Mobility Research Centre

Human Mobility Research Centre

Human Mobility Research Centre

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Our next CBME/HMRC seminar is November 20th at 1:30 pm.  Dr. Laurence Yang from the Department of Chemical Engineering (Queen's University) will be giving a seminar on "Modeling cellular responses to chemical stimuli--toward systems biomedicine".  Please see the abstract below. 

Speaker: Dr. Laurence Yang (Dept of Chemical Engineering, Queen's University)

When: November 20th at 1:30 pm

Location: HMRC Innovation Lab


Adaptation to physical and chemical stress is crucial for the survival of microbes. Heightened stress tolerance has been associated with antibiotic resistance and recurring infections but the exact role of stress response in these contexts is unclear. We are developing computational models to characterize the mechanisms of microbial stress response for Escherichia coli under three stresses: oxidative, pH, and thermal. We produce laboratory-evolved strains of E. coli having heightened stress tolerance and use our models to explain how the observed mutations and transcriptome alterations contribute to stress tolerance. We outline how our models have advanced knowledge of each of the three stress responses. Finally, we discuss recent work on interfacing mechanistic modeling with machine learning to perform data-driven discovery and explain causal mechanisms.