Research | Queen’s University Canada

Improper Storage of von Willebrand Factor in an Endothelial Cell

This is an endothelial cell, the cell type that lines your blood vessels. This cell is neat because we grew it from a routine blood sample of a person with a common bleeding disorder, von Willebrand disease (VWD), and used it to figure out how their genetic mutation lead to a deficiency of von Willebrand factor (VWF), a vital clotting protein. VWF (green) is supposed to be stored in rod-shaped packets, but we found that proper storage was eliminated in this cell. Likely, the VWF is trapped, and cannot escape the cell to help with clotting.
Submission Year: 
Photographer's affiliation: 
Graduate student
Academic areas: 
Graduate Studies and Postdoctoral Affairs
Health Sciences
Improper Storage of von Willebrand Factor in an Endothelial Cell
Grad student
School of Graduate Studies
Faculty of Health Sciences
School of Medicine
Department of Pathology and Molecular Medicine
Fundamental Principles of Nature: from Discovery to Application and Innovation
Health, Wellness and the Determinants of Human Health
Location of photograph: 
Molecular Hemostasis Laboratory, Queen's University
Photographer's name: 
Lara Casey
Display Photographers Affiltion + Faculty or Department: 
Graduate Student, Pathology and Molecular Medicine