Chin-Sang Lab Publications


Molecular and Cellular Endocrinology CoverRain Zhu and Ian D. Chin-Sang (2024). C. elegans insulin-like peptides. Molecular and Cellular Endocrinology: vol. 585;



IJMSDaniel C. Quesnelle, William G. Bendena and Ian D. Chin-Sang (2023). A Compilation of the Diverse miRNA Functions in Caenorhabditis elegans and Drosophila melanogaster Development. International Journal of Medical Sciences: 24(8), 6963;



Developmental BiologyQuesnelle DC, Huang C, Boudreau JR, Lam A, Paw J, Bendena WG, Chin-Sang ID (2023). C. elegans vab-6encodes a KIF3A kinesin and functions cell non-autonomously to regulate epidermal morphogenesis. Developmental Biology  2023 Mar 7;497:33-41. DOI: 10.1016/j.ydbio.2023.02.010



micro publicationErmakova G, Hou C, Boudreau J, Bendena WG, Chin-Sang ID(2022). Characterizing Variants of Unknown Significance of the PTEN tumour suppressor Homolog DAF-18. MicroPubl Biol. DOI: 10.17912/micropub.biology.000689. eCollection 2022. PMID: 36530472


peptidesSanaz G Biglou, William G Bendena, Ian Chin-Sang (2021). An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans.  Peptides DOI: 10.1016/j.peptides.2021.170640




General and Comparative EdocrinologyBendena WG, Hui JHL, Chin-Sang I, Tobe SS (2020). Neuropeptide and microRNA Regulators of Juvenile Hormone Production. Gen. Comp. Endocrinol. doi: 10.1016/j.ygcen.2020.113507. PMID: 32413346 Review.



DevelopementShanqing Zheng, Zhi Qu, Michael Zanetti, Brandon Lam, Ian Chin-Sang (2018).  C. elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-Insulin-PP2A-MAPK pathway. Development DOI: 10.1242/dev.166876


micro publicationDhillon, I., Momin, A. and Chin-Sang, I. (2018). GABA Receptor mutant gbb-1 accelerates morphological aging of GABA neurons in Caenorhabditis elegans. Micropublication: Biology


JBCShanqing Zheng, Hilton Chiu, Jeffrey Boudreau, Tony Papanicolaou, William Bendena, Ian Chin-Sang (2018) A functional study of all 40 C. elegans insulin-like peptides. The Journal of Biological Chemistry DOI: 10.1074/jbc.RA118.004542

William Bendena  and Ian D. Chin-Sang (2018). Fine tuning of behaviors through neuropeptide signaling in Caenorhabditis elegans.  Invertebrate Endocrinology in press

Shanqing Zheng, Hilton Chiu, Jeffrey Boudreau, Tony Papanicolaou, William Bendena, Ian Chin-Sang (2018). A functional study of all 40 C. elegans insulin-like peptides. BioRxiv 336750; doi:


joveJason C. Campbell, Ian D. Chin-Sang, William G. Bendena (2017).  A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay.  Journal of Visualized Experiments (JoVE).



PLOS GeneticsWalck-Shannon E, Lucas B, Chin-Sang I, Reiner D, Kumfer K, Cochran H, et al. (2016) CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis. PLoS Genetics.


PLOS GeneticsCampbell JC, Polan-Couillard LF, Chin-Sang ID, Bendena WG (2016). NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans. PLoS Genet. 2016 May 25;12(5):e1006050. doi: 10.1371/journal.pgen.1006050. PMID: 27223098 

Shanqing Zheng and Ian D. Chin-Sang (2016). C. elegans Methods to Study PTEN. Methods in Molecular Biology. ISBN 978-1-4939-3299-3


PeptidesJason C. Campbell, Ian D. Chin-Sang, William G. Bendena (2014). Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch. Peptides doi:10.1016/j.peptides.2014.12.004

Jun Liu , Ian D. Chin-Sang (2014). C. elegans as a model to study PTEN’s regulation and function. Methods. doi:10.1016/j.ymeth.2014.12.009

ActaCrystalQiang Wei, Jun Liu, Nan Wang, Xiaoying Zhang, Jin Jin, Ian Chin-Sang, Jimin Zhenga and Zongchao Jia (2014). Structures of an Eph receptor tyrosine kinase and its potential activation mechanism.  Biological Crystallography. PMID: 25478832


SciencePulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A Unified Nomenclature and Amino Acid Numbering for Human PTEN (2014). Science  Signaling. PMID: 24985344


Jordan D.S. Zelt, Ian D. Chin-Sang, Lois M. Mulligan (2013). A novel C. elegans animal model for human RET receptor function. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research AACR; Cancer Res 2013;73(8 Suppl): doi:10.1158/1538-7445.AM2013-1580

PLOS OnePaul P. Su; Foroozan Torki; Tony Papanicolaou; Jeff R. Boudreau; Ian D. Chin-Sang; William G Bendena. Caenorhabditis elegans neuropeptide genes nlp-5 and nlp-6 regulate locomotory and egg-laying behavior (accepted). PLoS ONE


OncogneneJun Liu, Stacy Visser-Grieve, Jeffrey Boudreau,  Benjamin Yeung, Samantha Lo, Gabriel Chamberlain, Fabian Yu, Tao Sun, Tony Papanicolau, Annie Lam, Xiaolong Yang, Ian Chin-Sang (2013). Insulin Activates the Insulin Receptor to Down-regulate the PTEN Tumor Suppressor. Oncogene.


joveOlivia Margie, Chris Palmer, and Ian Chin-Sang (2013). C. elegans Chemotaxis Assay. Journal of Visualized Experiments (JoVE).



Current biologyAllison Lynch, Theresa Grana, Elisabeth Cox-Paulson, Anabelle Couthier, Michel Cameron, Ian Chin-Sang, Jonathan Pettitt, Jeff Hardin  (2012). A Genome-wide Functional Screen Shows MAGI-1 Is an L1CAM-Dependent Stabilizer of Apical Junctions in C. elegans.  Current Biology doi: 10.1016/j.cub.2012.08.024



WormbookMichael Miller and Ian Chin-Sang (2012). Eph Receptor Signaling in C. elegans. WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1,  


Front EndiocronologyWilliam Bendena, Jason Campbell, Lian Zara, Stephen S Tobe, Ian Chin-Sang(2012). Select neuropeptides and their G-protein coupled receptors in Caenorhabditis elegans and Drosophila melanogaster. Frontiers in Experimental Endocrinology 3:93:1 doi: 10.3389/fendo.2012.00093.


PLOS OneWang, C., Chin-Sang, I., Bendena, W.G. (2012) The FGLamide-allatostatins influence foraging behaviour in Drosophila melanogaster. PLoS ONE 7(4): e36059. doi:10.1371/journal.pone.0036059.



PLOS GeneticsAhmed Mohamed, Jeffrey Boudreau, Fabian Yu, Jun Liu and Ian D. Chin-Sang(2012). The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. PLoS Genetics 8(2): e1002513. doi:10.1371/journal.pgen.1002513


Cell deathLi X, Johnson RW, Park D, Chin-Sang I, Chamberlin HM (2012). Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans.  Cell Death Differ. doi: 10.1038/cdd.2011.192.


Anita Fernandez, Annie Lam, and Ian Chin-Sang. (2012) Real-time Embryogenesis in Live Caenorhabditis elegans Worms. The American  Physiological Society #R6064.


Developemental BiologyAhmed Mohamed and Ian D. Chin-Sang (2011). The C. elegans nck-1 gene encodes two isoforms and is required for neuronal guidance. Developmental Biology 354(1):55-66.



 Developmental CellSarah Brisbin, Jun Liu, Jeffrey Boudreau, Jimmy Peng, Marie Evangelista and Ian D. Chin-Sang (2009). A Role for C. elegans Eph RTK Signaling in PTEN Regulation. Developmental Cell 17(4): 459-469 [Science Editor's Choice] [Must Read Faculty of 1000] [Top 25 Hottest Article]


Ian Chin-Sang and Weiwei Zhong (2009). Using LEDs as a low-cost source to detect GFP and DsRED. Worm Breeder’s Gazette VOLUME 18, NUMBER 1:


PNAS William G. Bendena, Jeffrey R. Boudreau, Tony Papanicolaou, Matt Maltby, Stephen S. Tobe  and  Ian D. Chin-Sang (2008). A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behaviour in response to feeding cues. PNAS 105(4):1339-42


Sarah E. Brisbin and Ian D. Chin-Sang (2007) Analysis of DAF-18/PTEN in VAB-1 Eph RTK Signaling.  McGill J. Med. 10(2): 157-175.


Developemental BiologyMohamed A., and Chin-Sang, Ian D. (2006). Characterization of Loss-of-Function and Gain-of-Function Eph Receptor Tyrosine Kinase Signaling in C. elegans axon guidance and cell migration. Developmental Biology 290:1: 164-176. 


Ian Chin-Sang (2005). The C. elegans VAB-1/Eph receptor tyrosine kinase functions with the SAX-3/Robo receptor during cell movements and axon guidance. Society for Developmental Biology 64th Annual Meeting. San Francisco California USA. Abstract Published Developmental Biology 283 (2): 575 

DevelopementGhenea, S., Boudreau, J.R., Lague, N.P. and Chin-Sang, Ian D. (2005).  The VAB-1 Eph Receptor Tyrosine Kinase and SAX-3/Robo neuronal Receptors function together during C. elegans embryonic morphogenesis. Development132, 3679-3690).

Vivegananthan, Usha, Chin-Sang, Ian D., Lum, David and Spence, Andrew  M., (accepted). Analysis of mutations affecting the Caenorhabditis elegans ankyrin repeat sex determination protein, FEM-1. Genesis (2005)


DevelopementChin-Sang, Ian D.  Moseley S.L., Ding, M., Harrington, R.J., George, S.E., and Chisholm, A.D. (2002). The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph Receptor. Development 129: 5499-5510. 


Trends in GeneticsChin-Sang, Ian D. and Chisholm, Andrew D. (2000).  Form of the worm: Genetics of Epidermal Morphogenesis in C. elegans.  Trends in Genetics. 16:(12) 544-551 [Cover Article]. 



CellChin-Sang, Ian D. George, S.E., Ding, M., Moseley, S.L., Lynch, A., and Chisholm, A.,D.,  (1999). The Ephrin VAB-2/EFN-1 Functions in Neuronal Signaling to Regulate Epidermal Morphogenesis in C. elegans. Cell 99: 781-790. 



 Genes and DevChin-Sang, Ian D., and Spence, Andrew M., (1996).  Sex Determining Protein FEM-2 is a Protein Phosphatase that Promotes Male Development and Interacts Directly with FEM-3. Genes & Development 10:2314-2325.