For a complete list of publications authored by the Graham lab and collaborators, view their Google Scholar profile.

Current Research

Our laboratory work explores two general areas of investigation: (1) cancer progression and (2) complications of pregnancy and their impact on subsequent health. Over the years, our research in cancer has focused on investigating mechanisms by which the tumour microenvironment contributes to malignant progression, and one of our longstanding interests has been on studying the effects of tissue oxygenation on the acquisition of malignant properties by cancer cells. More recently, our emphasis has been on examining interactions between cancer cells and immune cells and on how these interactions can either promote survival or elimination of tumour cells. Our pregnancy research focuses on understanding the role of aberrant inflammation in the pathophysiology of common complications of pregnancy such as pre-eclampsia, intrauterine growth restriction and fetal loss, and on how inflammation in pregnancy can increase the risk of cardiovascular and metabolic disease later in life in the affected mothers and their offspring.


Immune System Diagram


Trained Immunity Acquisition



Pregnancy Complications





  • Canadian Institutes of Health Research
  • Southeastern Ontario Academic Medical Organization