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From Dr. Mulder:

32. Kehar M, Black K, Chu C, Kohli R, Mohammad S, Alrabadi L, Amendola M, Aqul A, Banc Husu A, Beretta MR, Chapin C, Cheng K, Diamond T, Goldstein M, Gumm A, Guttman O, Gupta N, Hildreth A, Hernandez Benabe S, Kohut T, Mackling J, Mulder DJ, Narang A, O'Donnell JEM, Ovchinsky N, Pai A, Raghu V, Swadera S, Waheed N, Watson N, Wood P. Severe hepatitis in pediatric patients: The Severe Hepatitis In Pediatric Patients (SHIPP) registry. J Pediatr Gastroenterol Nutr. May 2025;1-6. doi: 10.1002/jpn3.70083

31. Ghasempour S, Warner N, Guan R, Rodari MM, … Mulder DJ, … Freeman SA, Parlato M, van Ham TJ, Muise AM. Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis. J Exp Med Dec 2024;221(12):e20240546. doi: 10.1084/jem.20240546

30. Lehan E, Briand P, O’Brien E, Amjad Hafeez A, Mulder DJ. Synergistic patient factors are driving recent increased pediatric urgent care demand. PLOS Digit Health 2024;3(8):e0000572. doi: 10.1371/journal.pdig.0000572

29. Pineau ON, Tripp DA, Kelly A, Mulder DJ. Living with Inflammatory Bowel Disease (IBD): A Modified Photovoice Study of Adolescent Mental Health. Gastroenterol Nurs. Jul 2024;22(6):X. doi: 10.12968/gasn.2024.0013

28. van Wylick C, Lewis L, Mulder DJ. Distinct Patterns of Liver Chemistry Changes in Pediatric Acute Hepatitis of Unknown Origin and COVID-19: A Systematic Review. Cureus 16(4): e58307. doi: 10.7759/cureus.58307

27. Subranmanian L, Coo H, Jane A, Flemming J, Acker A, Hoggan B, Griffiths R, Sehgal A, Mulder DJ. Immune-mediated Gastrointestinal Diseases are Associated with Increased Risk of Eating Disorders: An Ontario Health Administrative Database Study. Clin Transl Gastroenterol. May 2024;15(5):e00700. doi: 10.14309/ctg.000000000000070

26. Yin G, Law C, Mulder DJ. Orbital cellulitis as first presentation of Crohn’s Disease in a Pediatric Patient. JFO Open Ophthalmology. Mar 2024;5:100098. doi: 10.1016/j.jfop.2024.100098

25. Lewis L, van Wylick C, Mulder DJ. A systematic review of the proposed etiologies of the 2021–2022 outbreaks of pediatric acute hepatitis of unknown etiology. Front Pediatr. Nov 2023;11:1285348. doi: 10.3389/fped.2023.1285348

24. Nambu R, Mulder DJ, Nakazawa A, Ishige T, Iwama I, Muise AM. Histopathological Features of Monogenic Inflammatory Bowel Disease: Sub-Analysis of Systematic Review. Gastro Hep Adv. Apr 2022;20(4):e653-e663. doi: 10.1016/j.gastha.2022.05.011

23. Sandy N, Huysentruyt K, Mulder DJ, Warner N, Alqhatani S, Muise AM, Wales P, Avitzur Y. The diverse phenotype of intestinal dysmotility secondary to ACTG2-related disorders. J Pediatr Gastroenterol Nutr. May 2022;74(5):575-581. doi: 10.1097/MPG.0000000000003400

22. Yao Y, Kim G, Shafer S, Chen Z, Kubo S, …, Mulder DJ, …, Snapper SB, Muise AM, Shouval DS, Ozen A, Pan K-T, Wu C, Lenardo MJ. Mucus sialylation determines intestinal host-commensal homeostasis. Cell. Mar 2022;185(7):1172-1188.e28. doi: 10.1016/j.cell.2022.02.013

21. Mulder DJ, Khalouei S, Li M, Warner N, Gonzaga-Jauregui C, Benchimol EI, Church PC, Walters TD, Ramani AK, Griffiths AM, Ricciuto A, Muise AM. Machine learning approach to identifying causal monogenic variants in inflammatory bowel disease. Gastro Hep Adv. Feb 2022;1(2):171-179. doi: 10.1016/j.gastha.2021.11.002

20. Leung G, Zhou Y, Ostrowski P, Mylvaganam S, Boroumand P, Mulder DJ, Guo C, Muse AM, Freeman S. ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells. JCI Insight. Oct 2021;6(23):e149376. doi: 10.1172/jci.insight.149376

19. Ryusuke N, Warner N, Mulder DJ, Kotlarz D, McGovern KPB, Cho J, Klein K, Snapper SB, Griffiths AM, Iwama I, Muise AM. A Systematic Review of Monogenic Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2021 Mar;S1542-3565(21)00331-1. doi: 10.1016/j.cgh.2021.03.021

18. Wang, L, Aschenbrenner D, Zeng Z, Cao X, …, Mulder DJ, …, Boztug K, Huang Y, Li D, Uhlig HH, Muise AM. Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. Nat Genet. 2021 Apr;53(4):500-510. doi: 10.1038/s41588-021-00803-4

17. Sherlock ME, Zachos M, Issenman RM, Mulder DJ. Clinical and laboratory characteristics are associated with biologic therapy use in pediatric inflammatory bowel disease: a retrospective cohort study. J Can Assoc Gastroenterol. 2021 Oct;4(5):e92-e100. doi: 10.1093/jcag/gwaa033

16. Mulder DJ, Khalouei S, Warner N, Gonzaga-Jauregui C, Church PC, Walters TD, Ramani AK, Griffiths AM, Cohn I, Muise AM. Utilization of Whole Exome Sequencing Data to Identify Clinically Relevant Pharmacogenomic Variants in Inflammatory Bowel Disease. Clin Transl Gastro. 2020 Dec;11(12):e00263. doi: 10.14309/ctg.0000000000000263

15. Putra J, Mulder DJ. Solitary Peutz-Jeghers type hamartomatous polyp in the transverse colon of an adolescent with ulcerative colitis. Dig Liver Dis 2019 Oct;S1590-8658(19)30795-9. doi: 10.1016/j.dld.2019.09.005

14. Mulder DJ, Sherlock ME, Lysecki DL. NMDA-receptor Antagonism in Pediatric Pancreatitis: Use of Ketamine and Methadone in a Teenager With Refractory Pain. J Pediatr Gastroenterol Nutr 2018 May;66(5):e134-136. doi: 10.1097/MPG.0000000000001907

13. Mulder DJ, Noble AJ, Justinich CJ, Duffin JM. A tale of two diseases: The history of inflammatory bowel disease. J Crohn Colitis. 2013 May;8(5):341-348. doi: 10.1016/j.crohns.2013.09.009

12. Mulder DJ, Hurlbut DJ, Noble AJ, Justinich CJ. Clinical features distinguish eosinophilic and reflux-induced esophagitis: an age-matched, case-controlled study and a novel scoring system. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):257-262. doi: 10.1097/MPG.0b013e3182794466

  • Selected for CME credit – objectives and test questions written by Mulder DJ

11. Mulder DJ, Mak N, Hurlbut DJ, Justinich CJ. Atopic and nonatopic eosinophilic esophagitis is distinguished by IgE-bearing intraepithelial mast cells. Histopath. 2012 Nov;61(5):810-822. doi: 10.1111/j.1365-2559.2012.4303.x

10. Mulder DJ, Lobo D, Mak N, Justinich CJ. Expression of toll-like receptors 2 and 3 on esophageal epithelial cell lines and on eosinophils during esophagitis. Dig Dis Sci 2012 Mar;57(3):630-642. doi: 10.1007/s10620-011-1907-4

9. Mulder DJ, Hookey LC, Hurlbut DJ, Justinich CJ. The impact of Crohn disease on eosinophilic esophagitis: evidence for an altered TH1-TH2 immune response. J Pediatr Gastroenterol Nutr 2011 Aug;53(2):213-215. doi: 10.1097/MPG.0b013e318213bf79

8. Mulder DJ, Justinich CJ. Understanding eosinophilic esophagitis: The cellular and molecular mechanisms of an emerging disease. Mucosal Immunol 2011 Mar;4(2):139-147. doi: 10.1038/mi.2010.88

7. Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ. Antigen presentation and MHC class II expression by human esophageal epithelial cells: Role in eosinophilic esophagitis. Am J Pathol 2011 Feb;178(2):744-753. doi: 10.1016/j.ajpath.2010.10.027

6. Mulder DJ, Hookey LC, Justinich CJ. Gone Fishin’: A surprising finding while investigating possible eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2010 Oct;51(4):377. doi: 10.1097/MPG.0b013e3181ec1d17

5. Gander S, Mulder DJ, Jones S, Ricketts JD, Soboleski DA, Justinich CJ. Recurrent abdominal pain and weight loss in an adolescent: Celiac artery compression syndrome. Can J Gastroenterol 2010 Feb;24(2):91-93. doi: 10.1155/2010/534654

4. Mulder DJ, Justinich CJ. B Cells, IgE and mechanisms of type I hypersensitivity in eosinophilic oesophagitis. Gut 2010 Jan;59:6-7. doi: 10.1136/gut.2009.189316

3. Mulder DJ, Gander S, Hurlbut DJ, Soboleski DA, Smith RG, Justinich CJ. Multiple squamous hyperplastic-fibrous inflammatory polyps of the esophagus: A new feature of eosinophilic esophagitis? J Clin Pathol 2009 Sep;62(9):845-846. doi: 10.1136/gut.2009.189316

2. Mulder DJ, Pacheco I, Mak N, Furuta GT, MacLeod RJ, Justinich CJ. FGF9-induced proliferative response to eosinophilic inflammation in esophagitis. Gut 2009 Feb;58(2):166-173. doi: 10.1136/gut.2008.157628

1. Justinich CJ, Mak N, Pacheco I, Mulder DJ, Wells RW, Blennerhassett MG, MacLeod RJ. The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A). Am J Physiol Gastrointest Liver Physiol 2008 Jan;294(1):G120-G129. doi: 10.1152/ajpgi.00226.2006