Thesis, Other Science Publications, and Theses Supervised
Lymphocyte Transformation. Forsdyke Ph.D thesis (1967)Multiauthor volumes
(1966-2014)
2. P. Milthorp and D. R.
Forsdyke. Proceedings 5th Leukocyte
Culture Conference Ed. Harris, J. Academic Press,
N.Y., p. l43-l7l. Activation by Con A and PHA of rat
lymphocytes in homologous or heterologous serum: dependence of
inhibition at high Con A/serum ratios on complement (l970b). 4. D. R. Forsdyke & F.W. Scott.
In: Cell Compartmentation and Metabolic Channelling
Ed. Lynen, F., Mothes, K., & Nover, L.
Elsevier, Amsterdam. pp. l77-l84. "Exogenous purine
deoxyribonucleosides do not prevent inhibition of DNA synthesis by
hydroxyurea: evidence for nonconvergence of de novo and
salvage pathways." (l979c). 5. D. R. Forsdyke.
Proceeding l3th Leukocyte Culture Conference
Ed. Kaplan, J. G., Elsevier, 6. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 11, 537-539 (2002).
Gregor Mendel. (also Nature Encyc. Hum. Genome.
2003)
Click Here 7. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 3, 115-117
(2002). William Bateson. (also Nature Encyc.
Hum. Genome. 2003)
Click
Here 8. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 16, 605-606
(2002). George Romanes.
Click
Here 9. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 12, 398-400
(2002). H.J. Muller.
Click
Here 10. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 8, 445-447
(2002). J.B.S. Haldane. (also Nature Encyc. Hum. Genome. 2003)
Click
Here 11. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 4, 239-240
(2002). E. Chargaff.
Click
Here 12. D. R. Forsdyke.
Nature Encyclopedia of Life Sciences 7,
396-403 (2002). Functional constraint and molecular evolution.
Click
Here
14. Forsdyke, D. R. In: Lewin's GENES XI
(2014) Editors. J. E. Krebs, S. T. Kilpatrick & E. S. Goldstein.
Revision of Chapter 4 ("The Interrupted Gene") and Section 6 of Chapter
8 ("How Did Interrupted Genes Evolve?"). Click
Here
Papers in Refereed Journals
(1966-1992)
Lectin-Activation of Cultured Lymphocytes -
Role of Serum Factors - RNA and DNA Synthesis
1. Quantitative nucleic acid
changes during PHA-induced lymphocyte transformation in vitro:
dependence of the response on the PHA/serum ratio. D.R. Forsdyke.
Biochem. J. l05, 679-684 (l967).
Click Here
2. The liquid scintillation
counter as an analogy for the distinction between "self" and "not-self"
in immunological systems. D.R. Forsdyke.
Lancet,
l, 28l-283 (l968a).
Click Here
3. Studies of the
incorporation of 5-[3H]uridine during activation and
transformation of lymphocytes induced by phytohaemagglutinin: dependence
of the incorporation rate on uridine concentration at certain critical
concentrations. D.R. Forsdyke.
Biochem. J. l07, l97-205 (l968b).
Click Here
4. Incorporation of [3H]-uridine
and attachment of cells to glass during activation of lymphocytes
induced by PHA. D.R. Forsdyke. Biochem. J.
l08, 297-302 (l968c).
Click Here
5. A theory of immunity. D. R.
Forsdyke. J. Theoret. Biol.
25, l73-l85
(l969a).
6. Impaired activation of thymus
lymphocytes by PHA. D. R. Forsdyke. J.
Immunol. l03, 8l8-823 (l969b).
7. Inhibition of lymphocyte
activation at high ratios of Con A to serum depends on complement.
P. Milthorp and D. R. Forsdyke. Nature
227, 1351-1352 (l970a).
8. Application of the isotope
dilution principle to the analysis of factors affecting the
incorporation of [3H]uridine and [3H]cytidine into
cultured lymphocytes: evaluation of pools in serum and culture media.
D. R. Forsdyke. Biochem. J. l25,
72l-732 (l97l).
Click Here
9. Isotope dilution analysis of
cell stimulation or inhibition by biological media. D. R. Forsdyke & P.
Milthorp. J. Immunol. Methods, l,
207-209 (l972a).
10.
Immunological defect in Whipple's disease.
A. Groll, L. Valberg, J. Simon, D. Eidinger, B. Wilson and D. R.
Forsdyke. Gastroenterology, 63,
943-950 (l972b).
11.
Serum factors affecting the incorporation of [3H]uridine
by lymphocytes stimulated by concanavalin-A: studies
of the role of complement. P. Milthorp & D. R.
Forsdyke. Biochem. J. l32,
803-8l2 (l973a).
Click Here
12.
A comparison of the activation of thymus and
lymph-node cells by concanavalin-A and phytohaemagglutinin.
P. Milthorp and D. R. Forsdyke. J. Immunol. Methods
2, 269-277 (l973b).
13.
Serum and lymphocyte activation by
phytohaemagglutinin. D. R. Forsdyke. Exp. Cell Research
77, 2l6-222 (l973c).
14.
Serum
factors affecting the incorporation of [3H]thymidine by
lymphocytes stimulated by antigen:
I. Serum
concentration. D. R. Forsdyke.
Immunology 25,
583-596 (l973d).
Click Here
15.
Serum factors affecting the
incorporation of [3H]thymidine by lymphocytes stimulated by
antigen: II.
Evidence for a role of complement from studies with heated serum. D.R.
Forsdyke. Immunology
25, 597-6l2
(l973e).
16.
Serum factors affecting the
incorporation of [3H]thymidine by lymphocytes stimulated by
antigen: III.
Evidence for a role of complement from studies with specific complement
inhibitors. D. R. Forsdyke
Immunology 25,
6l3-6l9 (l973f).
Click Here
17.
Isotope dilution analysis of rate-limiting steps and
pools affecting the incorporation of thymidine and deoxycytidine into
cultured thymus cells. D. A. Sjostrom & D. R. Forsdyke.
Biochem. J. l38, 253-262
(l974).
Click Here [More detailed studies of thymic
nucleic acid synthesis under culture conditions in the hope of later
employing nucleic acid precursors to examine thymic function more
exhaustively.]
18.
Further implications of a theory of immunity.
D. R. Forsdyke.
J. Theoret. Biol.
52, l87-l98
(l975a). Click Here
19.
Evidence for a relationship between chloroquine and
complement: Possible implications for the mechanism
of action of chloroquine in disease. D. R. Forsdyke.
20.
Isotope dilution studies of the effects of
5-fluorodeoxyuridine and hydroxyurea on the incorporation of
deoxycytidine and thymidine by cultured thymus cells.
F.W. Scott & D. R. Forsdyke. Can. J.
Biochem. 54, 238-248 (l976).
21. Stimulation by autologous serum preheated at 66oC of
the incorporation of [3H]uridine by cultured
lymphocytes: comparison with stimulation by
concanavalin-A. C. M. David & D. R. Forsdyke.
22.
Role of receptor aggregation in complement-dependent
inhibition of lymphocytes by high concentrations of Con-A.
D. R. Forsdyke. Nature, 267,
358-360 (l977b). [More detailed studies of the lectin
pathway of complement activation under culture conditions.]
23.
Role of complement in the toxicity of dietary
legumes. D. R. Forsdyke.
Medical Hypothesis,
4,
97-100 (1978a).
24. The rate of DNA synthesis by cultured Chinese Hamster
ovary cells: an application of isotope dilution analysis.
F.W. Scott & D. R. Forsdyke. Biochem. J.
170, 545-549 (1978b).
Click Here
[Demonstration that, when pools are taken into
account, 3H-thymidine incorporation
rate can reflect the actual rate of DNA synthesis under culture conditions.]
25. Comparison of enhancement by heated serum and 2-mercaptoethanol of lymphocyte transformation induced by high concentrations of concanavalin-A. D. R. Forsdyke & C. M. David. Cellular Immunology, 36, 86-96 (1978c).
(1)
A comparison of short and multiple choice
questions in the evaluation of students of biochemistry.
D. R. Forsdyke. Medical Education
12, 351-356
(1978d).
26.
Serum factors affecting the
incorporation of [3H]thymidine by lymphocytes stimulated by
antigen. IV.
Comparison of enhancement by heated (56oC) serum and by
2-mercaptoethanol. D. R. Forsdyke.
Int. Arch. Allergy Appl. Imm.
60,
89-96 (1979a).
27.
Early-onset inhibition of lymphocytes in heterologous
serum by high concentrations of concanavalin-A. Further studies of the
role of complement with suramin and heated serum. D. R. Forsdyke and P.
Milthorp. Int. J. Immunopharmacology
1, 133-139 (l979b).
28. Isotope dilution analysis of the effects of
deoxyguanosine and deoxyadenosine on the incorporation of
thymidine and deoxycytidine by hydroxyurea-treated thymus cells.
F. W. Scott and D. R. Forsdyke. Biochem. J.
l90, 72l-730 (l980a).
Click Here
29. Lectin pulses as determinants of lymphocyte
activation and inactivation during the first six hours of culture:
sequential action of concanavalin-A and complement cause cell lysis.
D. R. Forsdyke. Canad. J.
Biochem. 58, 1387-1396 (1980b).Click
Here
30.
Are introns in-series error detecting sequences?
D. R. Forsdyke.
J. Theoret. Biol.
93, 861-866
(1981). Click Here
Membrane Lipids, Cell Aggregation Phenomena, Change in Serum in Disease States (Erythrocyte Sedimentation Rate)
31. Role of serum in inhibition of cultured lymphocytes
by lysophosphatidylcholine. A. Takeda, R. G. E.
Palfree & D. R. Forsdyke. Biochim. Biophys. Acta
710, 87-98 (1982a).
Click Here
32.
Formation of erythrocyte rouleaux in preheated normal
serum: roles of albumin polymers
and lysophosphatidylcholine. D. R. Forsdyke, R. G. E.
Palfree & A. Takeda. Canad. J. Biochem. 60,
705-711 (1982b).
33.
Rouleau formation as a measure of the
phase-separating ability of plasma. D. R. Forsdyke &
P.M. Ford. J.
Theoret. Biol.
103, 467-472 (1983a).
34.
Segregation into separate rouleaux of erythrocytes
from different species: evidence against the agglomerin hypothesis of
rouleaux formation. D. R. Forsdyke & P. M. Ford.
Biochem. J. 214, 257-260
(1983b).
Click Here
Complementary DNA Cloning and Characterization of Lymphocyte Activation
"G0S" Genes
35.
Purification of Oligo dG-tailed Okayama-Berg linker
DNA fragments by oligo[dC]cellulose chromatography. D. R. Forsdyke.
Anal. Biochem. 137, 143-145
(1984a).
36.
Rapid qualitative changes in mRNA populations in
cultured human lymphocytes: comparison of the effects of cycloheximide
and concanavalin-A. D. R. Forsdyke.
Canad. J. Biochem. 62, 859-865 (1984b).
37.
cDNA cloning of mRNAs which increase rapidly in human
lymphocytes cultured with concanavalin-A and cycloheximide.
D. R. Forsdyke. Biochem. Biophys. Res. Comm.
129, 619-625 (1985a).
38.
Heat shock proteins defend against intracellular
pathogens: a non-immunological basis for self/non-self discrimination.
D. R. Forsdyke. J. Theoret. Biol.
115, 471-473
(1985b). Click Here
39.
A set of human putative lymphocyte G0/G1 switch genes
includes genes homologous to rodent cytokine and zinc finger
protein-encoding genes. Siderovski, D. P., Blum, S., Forsdyke, R. E. &
Forsdyke, D. R. DNA Cell Biol. 9,
579-587 (1990a).
40.
Three human homologs of a murine gene encoding an
inhibitor of stem cell proliferation. Blum, S., Forsdyke, R. E., &
Forsdyke, D. R. DNA Cell Biol.
9, 589-602 (1990b).
41.
Programmed activation of T-lymphocytes. A theoretical
basis for short-term treatment of AIDS with azidothymidine. D. R.
Forsdyke. Medical Hypothesis.
34, 24-21 (1991a).
Click Here
42.
Early evolution of MHC polymorphism. D. R. Forsdyke.
J. Theoret. Biol.
150, 451-456
(1991b). Click Here
43.
A human putative lymphocyte G0/G1 switch gene
containing a CpG-rich island encodes a small basic protein with the
potential to be phosphorylated. Russell, L. & Forsdyke, D. R.
DNA Cell Biol.
10, 581-591 (1991c).
44. Two signal model of self/not-self immune discrimination: an update. Forsdyke, D. R. J. Theoret. Biol. 154, 109-118. (1992). Click Here |
Theses Supervised
Student | Date | Degree | Thesis Title |
Peter Milthorp | September 1970 | M. Sc. | A Study of the Activation of Rat Lymphocytes by Concanavalin-A |
Dolores Anne Sjostrom | August 1972 | M. Sc. | Studies on the Incorporation of 3H-Thymidine into DNA of Rat Thymus Cells In Vitro. An Application of Isotope-Dilution Analysis |
Claudette Madeleine David | October 1975 | M. Sc. | Studies on the Activation of Rabbit Lymphocytes by Preheated (66oC) Serum. A Comparison to Stimulation by Concanavalin-A |
Fraser Wallace Scott | August 1976 | Ph. D. | Studies of the Incorporation of Thymidine and Deoxycytidine by Cultured Mononuclear Cells. Effects of Nucleosides, Hydroxyurea and 5' Fluorodeoxyuridine |
Kimberley Ann Johnston | December 1980 | M. Sc. | Proliferation of Rabbit Lymph Node Cells In Vitro |
Akiko Takeda | November 1980 | Ph. D. | Role of Serum in the Inhibition of Cultured Lymph Node Cells by Lysophosphatidylcholine |
James D. Waring | February 1986 | M. Sc. | Preparation of a Human Lymphocyte cDNA Expression Library by the Method of Okayama and Berg |
Shulamit Blum | May 1989 | M. Sc. | Genomic Structure of Two Members of a Human T-Lymphocyte Putative G0 /G1 Switch Gene Family [G0S19-1 and G0S19-2] |
David P. Sideris [later Siderovski] | April 1989 | B. Sc. Independent Study 596 | Characterization of G0/G1 Switch Genes in Cultured T Lymphocytes (Further information: Click Here) |
Scott Patrick Heximer | April 1997 | Ph.D. | Studies on Two Putative G0/G1 Switch Genes in Human T Lymphocytes, RGS2/G0S8 and G0S24 |
Anthony D. Cristillo | February 1998 | Ph.D. | Characterization of G0/G1 Switch Genes in Cultured T Lymphocytes |
Return to: HomePage (Click Here)
Return to: Forsdyke Laboratory Page (Click Here)
Go to: Evolution Page (Click Here)
Go to: Bioinformatics Page (Click Here)
This page was established in January 2007 and was last edited 20 Feb 2021 by Donald Forsdyke