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CHEE 324 Organic Process Development Units: 3.50
Students will expand their knowledge of functional group interconversions and C-C bond forming reactions learned in ENCH 245, and apply retrosynthetic analysis to propose multi-step syntheses of organic target molecules. Selection of reagents, solvents and reaction conditions will be examined in the context of process safety, reaction yield, product isolation, and profitability. This will be followed by studies of target molecule recovery by extraction, recrystallization, distillation and chromatography. The design component of the course is a series of two-hour design challenges in which student teams generate solutions to process development problems. This includes proposing reaction sequences for producing a target molecule, conducting safety analyses of hazardous reactions, choosing from multiple synthetic routes, and recommending separation trains for product isolation.
(Lec: 3, Lab: 0, Tut: 0.5)
(Lec: 3, Lab: 0, Tut: 0.5)
Offering Term: W
CEAB Units:
Mathematics 0
Natural Sciences 12
Complementary Studies 0
Engineering Science 15
Engineering Design 15
Offering Faculty: Smith Engineering
Course Learning Outcomes:
- Devise methodologies for quenching reaction mixtures and isolating target molecules, including appropriate use of liquid-liquid extraction, distillation, chromatography, recrystallization and trituration.
- Design multistep reaction sequences leading to the synthesis of organic molecules containing up to three functional groups.
- Evaluate organic syntheses taken from the scholarly and patent literature on aspects of process safety, environmental impact, economics and operability.
- Compare pathways for the synthesis of an organic molecule based on process safety, environmental impact, economics and operability.
- Depict multi-step organic processes using appropriate block flow diagrams.