RauhLab

Department of Pathology and Molecular Medicine

RauhLab

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Selected Publications

Front cover of the journal "Immunity"

Rauh et al., cover issue of Immunity, Volume 23, Issue 4. SHIP represses the generation of alternatively activated macrophages. See the full text 

For a complete list of publications authored by Dr. Rauh, go to the publications list or look at his Google Scholar profile

Most Significant Contributions

Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Damen JE, Huxham L, Minchinton AI, Mui A L-F, and Krystal G. SHIP represses the generation of alternatively activated macrophages. Immunity. 2005 Oct; 23(4): 361-74.

Significance: This publication identified SHIP as a novel regulator of macrophage programming, of potential therapeutic importance in cancer-related immunosuppression and lung pathology. Moreover, it was one of the first publications to demonstrate that macrophage polarization can occur during differentiation, in response to the microenvironment.

See the abstract at the Immunity journal website


Cull A, Snetsinger B, Mumal I, Shan F, Good D and Rauh MJ.  Increased arginase 1 expression in human MDS, CMML and murine models points to dysregulation of common immunosuppressive signaling networks.  Blood Abstract 2013 122:1578 and manuscript in preparation.

See the recent abstract at the American Hematology Society website

Rauh MJ, Mahendru D, Shapiro R, Chesney A, Good D, Reis M, Lam A, Krystal G, Buckstein R, and Wells RA. Arginase and YKL-40, effectors of immunosuppressive myeloid cells, are overexpressed in the bone marrow of lower-risk MDS and CMML patients. Blood Abstract, 2010; 116: 1855.

See the abstract at the American Hematology Society website

Significance: These studies resulted from careful clinical observation and translational research to human patients with myeloid neoplasms. These studies were among the first to identify the role of immunosuppressive myeloid cells in hematological neoplasms. They demonstrate the ability to conduct successful and collaborative translational QMyPath research in the RauhLab.


Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity. 2004 Aug; 21(2): 227-39.

See the abstract at the Immunity journal website

Significance: This publication identified SHIP as a novel regulator of endotoxin tolerance and innate immune signal transduction emanating from Toll-like receptors.


Rauh MJ, Blackmore V., Andrechek E.R., Tortorice C.G., Daly R., Lai V.K., Pawson T., Cardiff R.D., Siegel P.M., Muller W.J. (1999). Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein. Mol. Cell Biol. 19:8169-79.

Significance: This publication demonstrated that Grb2 and Shc adaptors sensitize mammary epithelial cells to growth factor receptor signaling during mammary tumourigenesis.

See the full paper at the American Society for Microbiology website