RauhLab

Department of Pathology and Molecular Medicine

RauhLab

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List of Publications

Journals

1. Yulei Zhao, Kathrin Tyrishkin, Calvin Sjaarda, Jeff Stafford, Prem Khanal, Michael Rauh, Xudong Liu, Tomas Babak, Xiaolong Yang. A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells (submitted). Cell Research. Submitted

2. Zhang G, Hopman W, Rauh MJ, Bhella S. (2018). Outcomes of Secondary Acute Lymphoblastic Leukemia: Case Report and Literature Review of 198 Cases. Leukemia Research Reports. n/a: n/a. Submitted.

3. Elina K. Cook, Terumi Izukawa, Sherylan Young, Gili Rosen, Mina Jamali, Liying Zhang, Dylan Johnson, Eva Bain, Jamie Hilland, Christina Ferrone, Jonah Buckstein, Janika Francis, Bushra Momtaz, Amy J. M. McNaughton, Xudong Liu, Brooke Snetsinger, Michael J. Rauh* and Rena Buckstein* (*co-senior authors). (2018). Co-morbid and inflammatory characteristics of age-related clonal hematopoiesis and its genetic subtypes. Blood. Submitted.

4. Bruno K L Duarte; Gabriela G Yamaguti-Hayakawa; Samuel S Medina; Lúcia H Siqueira; Brooke Snetsinger, Fernando F Costa,; Michael J Rauh and Margareth C Ozelo. (2018). Clonal dynamics in transformed RUNX1-mutated FPDMM: report of two new mutations and systematic review. Blood Advances. Submitted. 

5. Helena J. Janse van Rensburg, Taha Azad, Min Ling, Yawei Hao, Brooke Snetsinger, Prem Khanal, Lori M. Minassian, Charles H. Graham, Michael J. Rauh, Xiaolong Yang. (2018). The Hippo pathway component TAZ promotes immune evasion in human cancer through PD-L1.Cancer Research. n/a: n/a. 

6. Cull AH, Mahendru D, Snetsinger B, Good DJ, Chesney A, Ghorab Z, Reis M, Buckstein R, Wells RA, Rauh MJ. (2017). Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. Leukemia Research. 65: 5-13. 

7. Cull AH, Snetsinger B, Buckstein R, Wells RA, Rauh MJ. (2017). Tet2 restrains inflammatory gene expression in macrophages. Experimental Hematology. 55: 56-70. http://dx.doi.org/http://dx.doi.org/10.1016/j.exphem.2017.08.001 

8. Yu J, Alharbi A, Shan HY, Snetsinger B, Rauh MJ, Yang X. (2017). TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating Aldh1a1. Oncotarget. 8(24): 38426-38443. 

9. Cull AH, Rauh MJ. (2017). Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes. Journal of Leukocyte Biology. 102(2): 209-219. 

10. Sekeres M, Othus M, List AF, Odenike O, Stone RM, Gore SD, Litzow MR, Buckstein R, Fang M, Roulston D, Bloomfield CD, Moseley A, Nazha A, Zhang Y, Velasco MR, Gaur R, Atallah E, Attar EC, Cook E, Cull A, Rauh MJ, Appelbaum FR, Erba HP. (2017). A randomized phase II study of azacitidine in combination with lenalidomide or with vorinostat vs. azacitidine monotherapy in higher-risk myelodysplastic syndromes and chronic myelomonocytic leukemia: North American intergroup study SWOG S1117. Journal of Clinical Oncology. 35(24): 2745-2753. 

11. Abegunde O, Buckstein R, Wells RA, Rauh MJ. (2017). An inflammatory environment containing TNF-alpha favours Tet2-mutant clonal hematopoiesis. Experimental Hematology. ePub Nov. 28:

12. Rauh MJ, Good DJ. (2014). Bodies of evidence? Lymphoglandular bodies in aspirate smears of bone marrow involved by aggressive large B-cell lymphoma.Blood. 123(24): 3695. 

13. Rauh MJ. (2014). Standardizing dysgranulopoiesis in MDS and AML: refining diagnostics and laying the foundation for novel morphological-genetic correlations.Leukemia Research. 38(4): 428-429.

14. Al Johani, N and Rauh MJ. (2013). Diagnose this: May-Hegglin anomaly. Queen’s Medical Review. 6(2): 31-32.  

15. Rauh MJ, Liesveld J, Burack RW, Bennett JM. (2012). Emergence of JAK2-mutant primary myelofibrosis in myelodysplastic syndrome: rare case report, literature review, and implications for clonal progression. Journal of Hematopathology. 5: 135-139. 

16. Rauh MJ , Rahman F , Good D , Silverman J , Brennan MK , Dimov N , Liesveld J , Ryan DH , Burack WR , Bennett JM. (2012). Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review.Leukemia research. 36(1): 81-86. 

17. Rauh MJ. (2012). (e-letter) Re: Parvovirus B19-induced pure red cell aplasia in a heart transplant recipient.Blood (e-letter) (21 Nov. 2012) http://www.bloodjournal.org/content/120/17/3395.e-letters. 

18. Rauh MJ , Al Habeeb A , Chang H. (2011). Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma.Pathology - Research and Practice. 207(2): 121-123. 

19. Kuroda E , Ho V , Ruschmann J , Antignano F , Hamilton M , Rauh MJ , Antov A , Flavell RA , Sly LM , Krystal G. (2009). SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils.Journal of immunology. 183(6): 3652-3660.

20. Sly LM , Ho V , Antignano F , Ruschmann J , Hamilton M , Lam V , Rauh MJ , Krystal G. (2007). The role of SHIP in macrophages.Frontiers in Bioscience. 12: 2836-2848.

21. Rauh MJ , Ho V , Pereira C , Sham A , Sly LM , Lam V , Huxham L , Minchinton AI , Mui A , Krystal G. (2005). SHIP represses the generation of alternatively activated macrophages.Immunity. 23(4): 361-374. P

22. Sly LM , Rauh MJ , Kalesnikoff J , Song CH, Krystal G. (2004). LPS-induced upregulation of SHIP is essential for endotoxin tolerance.Immunity. 21(2): 227-239. 23. Rauh MJ , Sly LM , Kalesnikoff J , Hughes MR , Cao LP , Lam V , Krystal G. (2004). The role of SHIP1 in macrophage programming and activation.Biochemical Society Transactions. 32(Pt 5): 785-788. 

24. Sly LM, Rauh MJ, Kalesnikoff J, Büchse T, Krystal G. (2003). SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide.Experimental Hematology. 31(12): 1170-1181.

25. Rauh MJ , Kalesnikoff J , Hughes M , Sly L , Lam V , Krystal G. (2003). Role of Src homology 2-containinginositol 5'-phosphatase (SHIP) in mast cells and macrophages.Biochemical Society Transactions. 31(Pt 1): 286-291.

26. Kalesnikoff J , Sly LM , Hughes MR , Büchse T , Rauh MJ , Cao LP , Lam V , Mui A , Huber M , Krystal G. (2003). The role of SHIP in cytokine-induced signaling.Reviews of Physiology, Biochemistry and Pharmacology. 149: 87-103.

27. Rauh, M. (2003). Canadian bacon: straight goods on the MD/PhD program experience from a student’s perspective. Science, Next Wave (now Science Careers). 2003(10)

28. Takeshita S , Namba N , Zhao JJ , Jiang Y , Genant HK , Silva MJ , Brodt MD , Helgason CD , Kalesnikoff J , Rauh MJ , Humphries RK , Krystal G , Teitelbaum SL , Ross FP. (2002). SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts.Nature Medicine. 8(9): 943-949.

29. Rauh MJ , Krystal G. (2002). Of mice and men: elucidating the role of SH2-containing inositol 5phosphatase (SHIP) in human disease.Clinical and Investigative Medicine. 25(3): 68-70.

30. Rauh MJ. (2002). An inspiring model for translational research: nuclear factor-kappaB (NF-kappaB), bench to bedside.Clinical and Investigative Medicine. 25(3): 65-66. 

31. Rauh MJ. (2002). The forecast is bright for budding clinician-scientists on Canada's west coast.Clinical and Investigative Medicine. 25(3): 66-67. 

32. Rauh MJ , Blackmore V , Andrechek ER , Tortorice CG , Daly R , Lai VK , Pawson T , Cardiff RD , Siegel PM , Muller WJ. (1999). Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.Molecular and Cellular Biology. 19(12): 8169-8179. 

33. Webster MA , Hutchinson JN , Rauh MJ , Muthuswamy SK , Anton M , Tortorice CG , Cardiff RD , Graham FL , Hassell JA , Muller WJ. (1998). Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis.Molecular and Cellular Biology. 18(4): 2344-2359.  

34. Appanna VD, Rauh M, Hamel R, Gauthier E. (1997). Isolation and characterization of an aluminum- sensitive mutant of Pseudomonas fluorescens. FEMS Microbiology Letters. 152: 287-292.

 

Book Chapters

1. Rauh MJ, Cook E, Bowdish DM. (2018). Myeloid-derived suppressor cells in aged humans. Fulop T, Franceschi C, Hirokawa K, Pawelec G. Handbook of Immunosenescence.

 

Conference Publications

1. Potus F.; Cook E.; Tian L.; Rauh M.; Archer S. (2018). Tet2 Deletion In Hematopoietic Cells Contributes To Pulmonary Arterial Hypertension Development (submitted to American Thoracic Society Meeting). American Thoracic Society Meeting, San Diego, United States, Conference Date: 2018/5

2. Lina Chen, Daniel Li, Kathrin Tyryshkin, Lan Deng, David Scott, Michael Rauh, Susan Crocker, Tara Baetz and David P. LeBrun. (2018). Objective Quantification of BCL2 Protein and Transcript in Routine Biopsy Samples Demonstrates Associations with BCL2 Translocation, BCL2 Copy Number Increase, and Response to R-CHOP in Patients with Diffuse Large B-cell Lymphoma (accepted poster). United States & Canadian Academy of Pathology’s 107th Annual Meeting, Vancouver, Canada, Conference Date: 2018/3 Poster

3. Cook E, Izukawa T, Young S, Rosen G, Jamali M, Snetsinger B, Johnson D, Bain E, Hilland J, Buckstein J, Francis J, Momtaz B, Buckstein R, Rauh MJ. (2017). Feeding the Fire: The Comorbid and Inflammatory Backdrop of Clonal Hematopoiesis of Indeterminate Potential (CHIP) By Mutation Subtype. Blood. 59th Annual ASH Meeting (oral presentation; featured also in Highlights of ASH and ASH Clinical News; manuscript in submission to Blood), Atlanta, United States (Vol 130, Suppl 1), Conference Date: 2017/12 Paper

4. Bruno K L Duarte, Samuel S Medina, Gabriela G Yamaguti Hayakawa, Fernando Ferreira Costa, Michael J. Rauh and Margareth C Ozelo. (2017). Somatic Mutations Associated with Myeloid Transformation of RUNX1-Mutated Familial Platelet Disorders with Propensity to Myeloid Malignancies Using Targeted Next- Generation Sequencing. Blood. 59th Annual ASH Meeting, Atlanta, United States (Vol 130, Suppl 1), Conference Date: 2017/12 Poster 

5. Rauh MJ, Ferrone C, Snetsinger B, Zhang X, Feilotter H. (2017). Path2MyDx: Personalized Molecular Pathology for Myeloid Cancer Diagnosis. 2nd Annual OICR/OMPRN Pathology Matters Meeting, Toronto, Canada, Conference Date: 2017/10 Poster 

6. E. K. Cook, T. Izukawa, D. Johnson, E. Bain, J. Hilland, B. Snetsinger, B. Momtaz, J. Francis, S. Young, G. Rosen, M. Jamali, J. Buckstein, M. Rauh, R. Buckstein. (2017). Clonal Hematopoiesis of Aging (CHIP) is Associated with Specific Immunological Parameters and Clinical Comorbidities: Toward Practical Screening in Older Adults. Leukemia Research. 14th International Symposium on MDS, Valencia, Spain (Vol55, Suppl1, S106), Conference Date: 2017/5 Poster

7. Cull A and Rauh MJ. (2016). Tet2 Deficiency Leads to an Increased Inflammatory Phenotype in Murine Macrophages. 58th Annual ASH Meeting, , Conference Date: 2016/12 Paper 

8. Kathrin Tyryshkin, Yi D Li, David Good, Lois E. Shepherd, Tara Baetz, Michael J. Rauh, MD, PhD and David P. LeBrun. (2016). Differential Expression of TCF3 Target Genes Defines Subclasses of Diffuse Large B-Cell Lymphoma with Striking Differences in Clinical Outcome Following R-CHOP Therapy. 58th Annual ASH Meeting, , Conference Date: 2016/12 Poster

9. Abegunde SO, Rauh MJ. (2016). TNF-Alpha Promotes Clonal Expansion of Tet2 Deficient Bone Marrow Progenitors in MDS. 58th Annual ASH Meeting, , Conference Date: 2016/12 Paper

10. Cull A and Rauh MJ. (2016). Microenvironmental Links Between TET2/DNMT3A Mutations and Arginase 1 Overexpression in Human MDS/CMML. 58th Annual ASH Meeting, , Conference Date: 2016/12 Poster

11. Cook E and Rauh MJ. (2016). The cytokine milieu may be gendered among hematologicallyhealthy people with clonal hematopoiesis of indeterminate potential. Canadian Conference on MDS, , Conference Date: 2016/9 Poster 

12. Cull A and Rauh MJ. (2016). Tet2 is a NovelRegulator of Murine Macrophage LPS-Associated Inflammatory Gene Expression. Canadian Conference on MDS, , Conference Date: 2016/9 Poster 

13. Johnson D and Rauh MJ. (2016). Detection and characterization of clonal hematopoiesis in the elderly. Canadian Conference on MDS, , Conference Date: 2016/9 Poster  

14. Climans T, Liederman Z, Rauh MJ. (2016). Evaluation of unexplained anemia with MDS features in hospitalized patients. Canadian Conference on MDS, , Conference Date: 2016/9 Poster 

15. Abegunde SO and Rauh MJ. (2016). TNF-Alpha Promotes Clonal Expansion of Tet2 Deficient Haematopoietic Progenitors in MDS. Canadian Conference on MDS, , Conference Date: 2016/9 Paper 

16. Susan F. Crocker, Michael Rauh, Kate Drummond, Henry Wong, Janet Lui, David Good, David Lee. (2016). Decoding a cryptic a case of Acute Promyelocytic Leukemia. Great Lakes Chromosome Conference (the National Canadian Cytogenetics Conference), Toronto, Canada, Conference Date: 2016/5 Paper

17. Cull A, Snetsinger B, Rauh MJ. (2015). Tet2 Is a Novel Regulator of Murine Macrophage Differentiation and Polarization. (Blood 2015 126:646). Blood. 57th Annual Meeting of the American Society of Hematology (ASH), United States (126:646), Conference Date: 2015/12 Paper Last Author Published Refereed?: Yes, Invited?: Yes

18. Abegunde S, Rauh MJ. (2015). Tet2-Deficient Bone Marrow Progenitors Have a Proliferative Advantage in the Presence of TNFa and IFNg: Implications for Clonal Dominance in Inflammaging and MDS (Blood 2015 126:2850). Blood. 57th Annual Meeting of the American Society of Hematology (ASH), United States (126:2850), Conference Date: 2015/12 Poster Last Author Published Refereed?: Yes, Invited?: Yes

19. DiMaria C Erica, Alex Trussler, Dyba Janique, David Lee, Michael J. Rauh, Paula D. James, Wilma Hopman, Annette E Hay. (2015). Testing for Heparin Induced Thrombocytopenia: Comparison of Practice at an Academic Center with Choosing Wisely Guidelines. Blood. 57th American Society of Hematology Meeting, United States (126:3469), Conference Date: 2015/12 Poster Co-Author Published Refereed?: Yes, Invited?: Yes

20. Snetsinger B, Heath E, Rauh MJ. (2015). Suspicious, Non-MDS-Diagnostic Bone Marrows Have a High Incidence of Clonal Hematopoiesis (CHIP), with MDS-like Clone Size but Restricted Mutation Burden Blood 2015 126:1668). Blood. 57th Annual Meeting of the American Society of Hematology (ASH), United States (126:1668), Conference Date: 2015/12 Poster Last Author Published Refereed?: Yes, Invited?: Yes

21. Cull A, Snetsinger B, Good D, and Rauh MJ. (2015). Macrophage populations may be skewed towards M2-polarization in TET2-deficient mice and human CMML. Leukemia Research. The 13th International Symposium on Myelodysplastic Syndromes, Washington, United States (39 (Suppl 1): S14), Conference Date: 2015/4 Abstract

22. Snetsinger B, Heath E, Good DJ, Buckstein R, Wells RA and Rauh MJ. (2015). Incidence and allele frequency of MDS-associated mutations through the spectrum of control, equivocal and diagnostic MDS bone marrows. Leukemia Research. 13th International Symposium on Myelodysplastic Syndromes, Washington, United States (39 (Suppl 1): S36), Conference Date: 2015/4 Abstract Last Author Accepted Refereed?: Yes, Invited?: Yes

23. Liederman Z, Climans T and Rauh MJ. (2015). Evaluation of unexplained anemia with MDS features in hospitalized patients. Leukemia Research. 13th International Symposium on Myelodysplastic Syndromes, Washington, United States (39 (Suppl 1): S38), Conference Date: 2015/4 Abstract Last Author Accepted Refereed?: Yes, Invited?: Yes

24. Abegunde SO, Park S, Cull A, Snetsinger B, Rauh MJ. (2014). Integrating novel molecular genetic tests in MDS practice: progress in the Queen's lab for personalized myeloid pathology and research. Canadian Conference on Myelodysplastic Syndromes (CCMDS), Banff, Canada, Conference Date: 2014/9 Poster Last Author Accepted Refereed?: Yes, Invited?: Yes

25. Cull A, Snetsinger B, Good D, Rauh MJ. (2014). TET2 inactivation may lead to M2-macrophage polarization in mouse and human MDS/ CMML (Young Investigator Research Program Award Winner). Canadian Conference on Myelodysplastic Syndromes (CCMDS), Banff, Canada, Conference Date: 2014/9 Abstract Last Author Published Refereed?: Yes, Invited?: Yes

26. Snetsinger B, Lin C, Weng W, Cull A, Sponagle K, Hough C, Lillicrap D, and Rauh MJ. (2013). Myeloid- Derived Suppressor Cell (MDSC) Dynamics In FVIII-Exposed Hemophilia A Mice: Novel Therapeutic Implications. Blood. American Society of Hematology (ASH), 55th Annual Meeting and Exposition, New Orleans, United States, Conference Date: 2013/12 Poster Last Author In Press Refereed?: Yes, Invited?: Yes

27. Cull A, Snetsinger B, Mumal I, Shan F, Good D, and Rauh MJ. (2013). Increased Arginase 1 Expression In Human MDS, CMML and Murine Models Points To Dysregulation Of Common Immunosuppressive Signaling Networks. Blood. American Society of Hematology (ASH), 55th Annual Meeting and Exposition, New Orleans, United States, Conference Date: 2013/12 Poster 

28. Rauh MJ, Good DJ. (2013). Acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 with development of systemic mastocytosis post induction chemotherapy. Workshop Case 88.Society for Hematopathology/ European Association for Hematopathology 2013 Workshop, MD Anderson Conference Center, Houston, United States, Conference Date: 2013/10 Abstract First Listed Author Published Refereed?: Yes, Invited?: Yes

29. Rauh MJ, Good DJ. (2013). Acute myeloid leukemia with t(9;22)(q34;q11.2); BCR-ABL1, and hyperdiploidy. Workshop Case 126.Society for Hematopathology/ European Association for Hematopathology 2013 Workshop, MD Anderson Cancer Center, Houston, United States, Conference Date: 2013/10 Abstract 

30. Rauh MJ, Mahendru D, Shapiro R, Chesney A, Good D, Reis M, Lam A, Krystal G, Buckstein R, and Wells RA. (2011). Arginase and YKL-40, Effectors of Immunosuppressive Myeloid Cells, are Over-Expressed in the Bone Marrow of Most Chronic Myelomonocytic Leukemia Patients, and Are Potential Prognostic Biomarkers in Myelodysplastic Syndrome. Inaugural Canadian Cancer Research Conference, CIHR-ICR New Investigator Forum, Toronto, , Poster 

31. Rauh MJ, Mahendru D, and Wells RA. (2010). Arginase and YKL-40, are novel biomarkers in MDS and CMML. Canadian Association of Pathologists (CAP) 61st Annual Meeting, , Poster 

32. Rauh MJ, Hsi ED, Richendollar BG, Sugimoto Y, Maciejewski JP, Bolwell BJ, O’Keefe C, and Smith SD. (2010). Single Nucleotide Polymorphism Array (SNP-A) Genomic Profiling of Mantle Cell Lymphoma (MCL) Against a Large Control Database Reveals Recurring Copy Number Alterations (CNAs) and Copy Neutral Loss of Heterozygosity (CN-LOH). 52nd American Society of Hematology (ASH) Meeting (Blood abstract and poster presentation), , Conference Date: 2010/12 Abstract  

33. Chan LSA, Gu LC, Rauh MJ, and Wells RA. (2010). Iron Overload Accelerates Development of Leukaemia: Evidence From a Mouse Model. 52nd American Society of Hematology (ASH) Meeting (Blood abstract and oral presentation), , Conference Date: 2010/12 Abstract 

34. Rauh MJ, Mahendru D, Shapiro R, Chesney A, Good D, Reis M, Lam A, Krystal G, Buckstein R, and Wells RA. (2010). Arginase and YKL-40, Effectors of Immunosuppressive Myeloid Cells, are Over-Expressed in the Bone Marrow of Most Chronic Myelomonocytic Leukemia Patients, and Are Potential Prognostic Biomarkers in Myelodysplastic Syndrome. 52nd American Society for Hematology (ASH) Meeting (Blood abstract & poster presentation), Orlando, United States, Conference Date: 2010/12 Poster

35. Rauh MJ, Webber L, Scott S, Shah K, Yang G, Chesney AE, and Reis MD. (2010). B-cell lymphoproliferative disorders with multiple clonal populations demonstrated by flow cytometric immunophenotyping. Canadian Association of Pathologists (CAP) 61st Annual Meeting, , Conference Date: 2010/5 Poster