Professor
Contact Information
Phone: 613.533.6465
Email: winnl@queensu.ca
Website
School of Environmental Studies, Department of Biomedical and Molecular Sciences
B.Sc. (University of Minnesota)
Ph.D. (University of Toronto)
Supervising
Please direct inquiries to the contact information provided.
Research Interests
My research focuses on mechanisms of developmental toxicity of both therapeutic and environmental chemicals. My research group uses experimental models and molecular techniques to assess this toxicity in a variety of ways including assessing the toxicity to both the placenta and to the fetus itself. Our ultimate goal is to understand the mechanisms by which chemicals cause toxicity to develop therapeutic strategies and interventions to reduce this toxicity.
Cull, M.E., Brown, L.T.L., Grant, P.M., Xue, L., Winn, L.M. (2026) Benzene-induced growth restriction and compensatory rebound in mouse fetuses and placentas. Reprod Toxicol. 2026 May;142:109231. doi: 10.1016/j.reprotox.2026.109231. Epub 2026 Apr 1. PMID: 41932658.
Brown, L.T.L., Cull, M.E., Pereira, D., Grant, P.M., Winn, L.M. (2026) Mind the Litter: The Critical Role of Intralitter Variables in Reproductive and Developmental Toxicology Research. Birth Defects Res. 2026 Apr;118(4):e70044. doi: 10.1002/bdr2.70044. PMID: 41986931; PMCID: PMC13083546.
Pereira, D., Bérard, A., Pleau, J., Leal, L.F., and Winn LM. (2026) Acetaminophen Use During Pregnancy and Neurodevelopmental Risk: Biological Plausibility. J Obstet Gynaecol Can. 2026 Jan;48(1):103192. doi: 10.1016/j.jogc.2025.103192. Epub 2025 Dec 1. PMID: 41338519.
Germain, L.S., Ott, B.P., Hindmarch, C.C.T., Winn, L.M. (2026) Triphenyl phosphate induces coordinated DNA methylation and gene expression changes in aquatic embryonic cells. Environ Epigenet. 2026 Jan 22;12(1):dvag003. doi: 10.1093/eep/dvag003. PMID: 41704671; PMCID: PMC12907732.
Bérard A., Cottin, J., Leal, L.F., Picot, C., Pleau, J., Friedman, J.M., Damkier, P., Cucherat, M., Alwan, S., Jurek, L., Winn, L.M., Carleton, B.C., Bertoldi, A.D., Grandi, S.M., Masarwa, R., Dodin, P., Ceulemans, M., Platt, R.W., Nourredine, M., Gram, E.B., Veroniki, A.A., Massardier, J., Tricco, A.C. (2026) Systematic review and meta-analysis: Acetaminophen use during pregnancy and the risk of neurodevelopmental disorders in childhood. J Am Acad Child Adolesc Psychiatry. 2025 Oct 6:S0890-8567(25)02106-9. doi: 10.1016/j.jaac.2025.09.031. Epub ahead of print. PMID: 41062061.
Germain, L.S. Winn L.M. (2025) Commercialization of cell and gene therapy in Canada: Current landscape, challenges and opportunities. Drug Discov Today. 2025 Aug 13:104453. doi: 10.1016/j.drudis.2025.104453. Epub ahead of print. PMID: 40816710.
Seabrook, K.J., Winn, L.M., Brinkmann, M., Adams, J.E., Canete, A., Xie, L., Peng, H., Robinson, S.A., Orihel, D.M. (2025) First assessment of the ecotoxicological effects of the tire antioxidant 6PPD on early life stages of the popular sport fish species, the largemouth bass (Micropterus nigricans). Environ Toxicol Chem. Jul 31:vgaf178. doi: 10.1093/etojnl/vgaf178. Epub ahead of print. PMID: 40741995.
Brown, L.T.L., Cull, M.E., Xue, L., Winn, L.M. (2025) Intralitter Variability Influences the Developmental impact of valproic acid exposure in CD-1 mice. J Appl Toxicol. Jul 21. doi: 10.1002/jat.4860. Epub ahead of print. PMID: 40692287.
Cull, M.E., Brown, L.T.L., Grant, P.M., Xue, L. and Winn, L.M. (2025) In utero benzene exposure in CD-1 mice results in increased fetal and placental size at gestational day 19, which is dependent upon intra-litter variables. Reprod Toxicol. Jun 25;136:108979. doi: 10.1016/j.reprotox.2025.108979. Epub ahead of print. PMID: 40578493.
Brown, L.T.L., Pereira, D. and Winn, L.M. (2025) A narrative review on the effect of valproic acid on the placenta. Birth Defects Res. 117(4):e2471. doi: 10.1002/bdr2.2471. PMID: 40211937; PMCID: PMC11986804.
Cull, M.E., Winn, L.M. (2025) Cull ME, Winn LM. Bisphenol A and its potential mechanism of action for reproductive toxicity. Toxicology. 511:154040. doi: 10.1016/j.tox.2024.154040. Epub 2024 Dec 25. PMID: 39725262.
Germain, L., Pereira, D. and Winn, L.M. (2025) Reference gene considerations for toxicological assessment of the flame retardant triphenyl phosphate in an in vitro fish embryonic model. J Appl Toxicol. 2025 Feb;45(2):288-297. doi: 10.1002/jat.4698. Epub 2024 Sep 18. PMID: 39295171.